Molecular structure of RK-682, Streptomyces sp., CAS Number: 154639-24-4
RK-682, Streptomyces sp. (CAS 154639-24-4)
Application:
RK-682, Streptomyces sp. is an effective tyrosine phosphatase inhibitor
CAS Number:
154639-24-4
Purity:
≥98%
Molecular Weight:
368.5
Molecular Formula:
C21H36O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RK-682 is an effective tyrosine phosphatase inhibitor that does not permeate the cell membrane. The inhibitor has been reported to inhibit the G1/S transition of the cell cycle, the dephosporylation activity of VHR and CD45, and also enhanced levels of phosphotyrosine in Ball-1 cells. VHR dephosphorylates activated ERK1/2 and reduces the strengths of the ERK signaling cascade. Studies demonstrate that RK-682 can enhance ATP-induced long term potentiation in guinea-pig hippocampal CA1 neurons.
RK-682, Streptomyces sp. (CAS 154639-24-4) References
- Baculovirus expression system: an alternative for producing catalytically active human PTP-1B. | Sundaram, S., et al. 2010. Mol Biol (Mosk). 44: 535-40. PMID: 20608179
- The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization. | Kase, Y., et al. 2022. iScience. 25: 104089. PMID: 35497000
- RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. | Hamaguchi, T., et al. 1995. FEBS Lett. 372: 54-8. PMID: 7556642
- The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons. | Fujii, S., et al. 1995. Neurosci Lett. 187: 130-2. PMID: 7783959
Inhibitor of:
CD45, PTP1B, and VHR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RK-682, Streptomyces sp. , 200 µg | sc-202791 | 200 µg | $107.00 |