Rit2 Antibody (27G2): sc-58474

Rit2 Antibody (27G2) is a mouse monoclonal IgG2b antibody that detects the Rit2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rit2 antibody (27G2) is available as the non-conjugated format. Rit2, also known as Ras like without CAAX 2, is a member of the Ras superfamily of small GTPases, notable for its lack of a CAAX motif, which is critical for cellular localization and functional dynamics. Predominantly expressed in the brain, Rit2 is integral to neuronal differentiation and cytoskeletal organization, and plays a significant role in neurotransmitter release, underscoring its importance in various neurological functions. Rit2′s structure, characterized by a unique GTP-binding domain, allows interaction with specific downstream effectors, influencing signaling pathways vital for maintaining neuronal health. This structural specificity enables Rit2 to modulate processes such as synaptic plasticity and neuronal survival, linking Rit2 to neurodegenerative diseases like Parkinson′s disease. By affecting dopaminergic neuron function, Rit2 may influence disease risk or progression, making Rit2 a promising target for therapeutic interventions aimed at understanding and treating neurodegenerative disorders. Rit2′s unique positioning in cellular signaling and neurological pathways emphasizes potential as a focal point for research into molecular mechanisms underlying neuronal function and pathology.

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Rit2 Antibody (27G2) References:

1. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.  |  Rusyn, EV., et al. 2000. Oncogene. 19: 4685-94. PMID: 11032018
2. The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.  |  Hoshino, M. and Nakamura, S. 2002. Biochem Biophys Res Commun. 295: 651-6. PMID: 12099688
3. Rit promotes MEK-independent neurite branching in human neuroblastoma cells.  |  Hynds, DL., et al. 2003. J Cell Sci. 116: 1925-35. PMID: 12668729
4. Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.  |  Shi, GX. and Andres, DA. 2005. Mol Cell Biol. 25: 830-46. PMID: 15632082
5. The RIN family of Ras effectors.  |  Bliss, JM., et al. 2006. Methods Enzymol. 407: 335-44. PMID: 16757336
6. Analysis of Rit signaling and biological activity.  |  Andres, DA., et al. 2006. Methods Enzymol. 407: 499-512. PMID: 16757348
7. Rin, a novel cell-surface protein that labels reticular neurons early in chick neurogenesis.  |  Chang, S. and Raible, DW. 1994. J Neurobiol. 25: 395-405. PMID: 8077965
8. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.  |  Lee, CH., et al. 1996. J Neurosci. 16: 6784-94. PMID: 8824319

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rit2 Antibody (27G2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Rit2 Antibody (27G2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rit2 Antibody (27G2) Specifications

Alternate Product Name: Rit2

Product Clone Name: 27G2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Rit2

Epitope Species: human

Product Reactivity/Detection: Rit2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 1% glycerol

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Rit2 Antibody (27G2): N/A