Rit2 Activators
Rit2 Activators suggests a class of compounds designed to modulate or influence biological processes related to a molecular target, presumably associated with the "Rit2" designation. These activators may act through various mechanisms, such as binding to specific receptors, enzymes, or other molecular entities involved in cellular signaling pathways. The nomenclature implies a focus on activating a particular pathway or biological response, potentially indicating a role in cellular regulation.
These compounds could be characterized by their chemical structure, which might include specific functional groups or motifs that confer their activator properties. Understanding the structure-activity relationships within the Rit2 Activators class would likely be crucial for optimizing their efficacy and selectivity. Researchers and scientists interested in this chemical class might explore its pharmacokinetics, bioavailability, and mechanism of action to unravel the intricacies of how Rit2 Activators interact with their biological targets. Further studies would be needed to elucidate the potential physiological consequences of activating Rit2 and to explore the broader implications of these compounds in the context of cellular and molecular biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can then phosphorylate and enhance Rit2 activity by promoting its GTP-bound state. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate various downstream effectors. PKC-mediated phosphorylation events have been shown to enhance Rit2 by promoting its active conformation and facilitating its interaction with other signaling proteins. | ||||||
Farnesyl thiosalicylic acid | 162520-00-5 | sc-205322 sc-205322A | 1 mg 5 mg | $60.00 $80.00 | 15 | |
FTS disrupts the localization and function of Ras proteins by dislodging them from cell membranes. This can indirectly enhance Rit2 activity by reducing competitive inhibition at shared downstream targets, allowing Rit2 to more effectively promote its signaling outcomes. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide (NO), which can activate soluble guanylate cyclase (sGC) and increase cGMP levels. Elevated cGMP can enhance Rit2 activity through cGMP-dependent protein kinases that may phosphorylate and activate Rit2 or its associated partners. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a PKA inhibitor that paradoxically can enhance Rit2 activity by preventing PKA from phosphorylating inhibitory sites on Rit2 or its interacting partners, thus maintaining Rit2 in an active state. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can lead to the activation of various proteins and pathways that may enhance Rit2 activity by promoting its stability or interaction with other signaling molecules. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), leading to an increase in cAMP levels, similar to Forskolin. The enhanced cAMP levels can activate PKA, which may then phosphorylate and activate Rit2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor. Inhibition of ROCK leads to changes in actin cytoskeleton dynamics. These changes can enhance Rit2 activity by facilitating its localization to areas of the cell where it can interact with other signaling molecules. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can enhance phosphorylation levels of proteins, potentially increasing Rit2 activity by preventing its dephosphorylation and maintaining it in an active state. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits PDE5, leading to an increase in cGMP levels. The increased cGMP can enhance Rit2 activity similarly to SNAP, by promoting the activity of cGMP-dependent kinases that may activate Rit2 or its associated signaling partners. | ||||||