Ribosomal Protein S7 Antibody (44-K): sc-100834
- Ribosomal Protein S7 Antibody (44-K) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant Ribosomal Protein S7 of human origin
- recommended for detection of Ribosomal Protein S7 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ribosomal Protein S7 Antibody (44-K). This work is in progress.
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Ribosomal Protein S7 Antibody (44-K) is a mouse monoclonal IgG1 antibody that detects Ribosomal Protein S7 (RPS7) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RPS7, a 194 amino acid protein, is an essential component of the 40S ribosomal subunit, playing a critical role in protein synthesis. RPS7 primarily localizes in the cytoplasm, contributing to ribosome assembly and interacting with key regulatory proteins such as MDM2. RPS7-MDM2 interaction is particularly significant as this binding negatively regulates MDM2-mediated degradation of tumor suppressor protein p53, influencing cellular responses to stress and apoptosis. RPS7 is implicated in ribosomal stress, linking ribosome biogenesis to critical cellular outcomes such as cell death or cell cycle arrest. Multiple processed pseudogenes scattered throughout the genome highlight the evolutionary complexity and regulatory mechanisms associated with RPS7, making anti-RPS7 antibody (44-K) a vital tool for studies related to cancer biology and cellular stress responses.
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Ribosomal Protein S7 Antibody (44-K) References:
- Tagging ribosomal protein S7 allows rapid identification of mutants defective in assembly and function of 30 S subunits. | Fredrick, K., et al. 2000. J Mol Biol. 298: 379-94. PMID: 10772857
- Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. | Chen, D., et al. 2007. Oncogene. 26: 5029-37. PMID: 17310983
- Ribosomal protein S7 is both a regulator and a substrate of MDM2. | Zhu, Y., et al. 2009. Mol Cell. 35: 316-26. PMID: 19683495
- Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation. | Gao, M., et al. 2013. Nucleic Acids Res. 41: 5210-22. PMID: 23563151
- Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia. | Menezes, MJ., et al. 2015. Hum Mol Genet. 24: 2297-307. PMID: 25556185
- BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. | Ba, Q., et al. 2017. J Mol Cell Biol. 9: 209-219. PMID: 28510697
- Structural insights into the complex of trigger factor chaperone and ribosomal protein S7 from Mycobacterium tuberculosis. | Li, Z., et al. 2019. Biochem Biophys Res Commun. 512: 838-844. PMID: 30928093
- Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome. | Matsuki, Y., et al. 2020. Sci Rep. 10: 19669. PMID: 33184379
- RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling. | Zhou, YJ., et al. 2024. J Exp Clin Cancer Res. 43: 45. PMID: 38326908
- Ribosomal protein S7: a new RNA-binding motif with structural similarities to a DNA architectural factor. | Hosaka, H., et al. 1997. Structure. 5: 1199-208. PMID: 9331423
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ribosomal Protein S7 Antibody (44-K) | sc-100834 | 100 µg/ml | $333.00 |