Ribosomal Protein L13A Antibody (C-11): sc-390131

Ribosomal Protein L13A Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ribosomal Protein L13A (RPL13A) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RPL13A antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RPL13A, also known as the 23 kDa highly basic protein, plays a crucial role in the assembly and function of the ribosome, specifically as a component of the 60S subunit, which is essential for protein synthesis in eukaryotic cells. RPL13A consists of 203 amino acids and is located in the cytoplasm, where RPL13A contributes to the formation of the ribosomal structure and facilitates the translation of mRNA into polypeptides. RPL13A′s importance extends beyond its structural role; RPL13A is also involved in the regulation of gene expression and cellular stress responses, making RPL13A a vital player in maintaining cellular homeostasis. The gene encoding RPL13A is mapped to human chromosome 19q13.42 and is associated with multiple processed pseudogenes throughout the genome, highlighting RPL13A′s evolutionary significance and the complexity of ribosomal protein gene families.

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Ribosomal Protein L13A Antibody (C-11) References:

1. Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome.  |  Higa, S., et al. 1999. Gene. 240: 371-7. PMID: 10580157
2. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control.  |  Mazumder, B., et al. 2003. Cell. 115: 187-98. PMID: 14567916
3. The molecular mechanics of eukaryotic translation.  |  Kapp, LD. and Lorsch, JR. 2004. Annu Rev Biochem. 73: 657-704. PMID: 15189156
4. Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation.  |  Chaudhuri, S., et al. 2007. RNA. 13: 2224-37. PMID: 17921318
5. Ribosomal protein l13a as a reference gene for human bone marrow-derived mesenchymal stromal cells during expansion, adipo-, chondro-, and osteogenesis.  |  Studer, D., et al. 2012. Tissue Eng Part C Methods. 18: 761-71. PMID: 22533734
6. An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.  |  Poddar, D., et al. 2013. J Immunol. 190: 3600-12. PMID: 23460747
7. Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis.  |  Das, P., et al. 2013. Mol Cell Biol. 33: 2829-42. PMID: 23689135
8. Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.  |  Basu, A., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 533-42. PMID: 24436370
9. Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer.  |  Molavi, G., et al. 2020. J Appl Biomed. 18: 46-53. PMID: 34907725
10. Loss of function of ribosomal protein L13a blocks blastocyst formation and reveals a potential nuclear role in gene expression.  |  Kour, R., et al. 2023. FASEB J. 37: e23275. PMID: 37902531
11. Structure and evolution of mammalian ribosomal proteins.  |  Wool, IG., et al. 1995. Biochem Cell Biol. 73: 933-47. PMID: 8722009
12. A map of 75 human ribosomal protein genes.  |  Kenmochi, N., et al. 1998. Genome Res. 8: 509-23. PMID: 9582194

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ribosomal Protein L13A Antibody (C-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Ribosomal Protein L13A Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ribosomal Protein L13A Antibody (C-11) Specifications

Alternate Product Name: Ribosomal Protein L13A

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 171-201

Epitope Target: Ribosomal Protein L13A

Epitope Species: human

Product Reactivity/Detection: Ribosomal Protein L13A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Ribosomal Protein L13A Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin