Rhotekin 2 Antibody (2C2): sc-517159
- Rhotekin 2 Antibody (2C2) is a mouse monoclonal IgG2a κ Rhotekin 2 antibody provided at 100 µg/ml
- raised against amino acids 1-163 representing full length Rhotekin 2 of human origin
- recommended for detection of Rhotekin 2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rhotekin 2 Antibody (2C2). This work is in progress.
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Rhotekin 2 Antibody (2C2) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Rhotekin 2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Rhotekin 2 antibody (2C2) is available as a non-conjugated format. Rhotekin 2, also known as PLEKHK1 (Pleckstrin homology domain-containing family K member 1), is a 609 amino acid protein predominantly expressed in bone marrow-derived cells, lymphocytes, and CD4 positive T-cells, suggesting its significant role in lymphopoiesis. The protein contains a pleckstrin homology (PH) domain, which is crucial for its interaction with phosphoinositides and other signaling molecules, thereby facilitating intracellular signaling pathways. This interaction is vital for various cellular processes, including cytoskeletal organization and cell migration, which are essential for immune responses and tissue homeostasis. Additionally, Rhotekin 2 is known to interact with several effector proteins, such as rhophilin and protein kinase N, which further underscores its importance in regulating Rho GTPase signaling pathways. The presence of three isoforms of Rhotekin, produced through alternative splicing, adds another layer of complexity to its functional diversity, allowing for specific regulatory roles in different cellular contexts.
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Rhotekin 2 Antibody (2C2) References:
- Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. | Gregorio-King, CC., et al. 2004. J Steroid Biochem Mol Biol. 88: 311-20. PMID: 15120425
- Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. | Collier, FM., et al. 2004. Biochem Biophys Res Commun. 324: 1360-9. PMID: 15504364
- Bone morphogenetic proteins. | Chen, D., et al. 2004. Growth Factors. 22: 233-41. PMID: 15621726
- Possible interaction of a Rho effector, Rhotekin, with a PDZ-protein, PIST, at synapses of hippocampal neurons. | Ito, H., et al. 2006. Neurosci Res. 56: 165-71. PMID: 16934893
- Rho GTPases and regulation of hematopoietic stem cell localization. | Williams, DA., et al. 2008. Methods Enzymol. 439: 365-93. PMID: 18374178
- Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. | Nagata, K., et al. 2009. Med Mol Morphol. 42: 9-15. PMID: 19294487
- Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. | Reid, T., et al. 1996. J Biol Chem. 271: 13556-60. PMID: 8662891
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rhotekin 2 Antibody (2C2) | sc-517159 | 100 µg/ml | $322.00 |