RhoGEF p115 Antibody (YN-12): sc-81901
- RhoGEF p115 Antibody (YN-12) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against recombinant RhoGEF p115 of human origin
- recommended for detection of RhoGEF p115 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RhoGEF p115 Antibody (YN-12). This work is in progress.
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RhoGEF p115 Antibody (YN-12) is a mouse monoclonal IgG2a antibody that detects RhoGEF p115 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RhoGEF p115 plays a crucial role in cellular signaling by acting as a guanine nucleotide exchange factor, specifically facilitating the activation of Rho GTPases, which are essential for regulating various cellular processes, including cytoskeletal dynamics and cell migration. RhoGEF p115 maintains cellular architecture and responds to extracellular signals, as dysregulation of Rho GTPases can lead to pathological conditions such as cancer and cardiovascular diseases. RhoGEF p115 is predominantly located in the cytoplasm, where RhoGEF p115 interacts with other signaling molecules to modulate Rho GTPase activity, thereby influencing cellular responses to growth factors and other stimuli. Anti-RhoGEF p115 antibody (YN-12) serves as an invaluable tool for researchers studying these critical cellular signaling pathways.
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RhoGEF p115 Antibody (YN-12) References:
- Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. | Wells, CD., et al. 2001. J Biol Chem. 276: 28897-905. PMID: 11384980
- A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. | Dubash, AD., et al. 2007. J Cell Sci. 120: 3989-98. PMID: 17971419
- Reversible translocation of p115-RhoGEF by G(12/13)-coupled receptors. | Meyer, BH., et al. 2008. J Cell Biochem. 104: 1660-70. PMID: 18320579
- Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. | Bhattacharyya, R., et al. 2009. Cell Signal. 21: 996-1006. PMID: 19249348
- P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. | Slattum, G., et al. 2009. J Cell Biol. 186: 693-702. PMID: 19720875
- Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. | Chen, Z., et al. 2011. Protein Sci. 20: 107-17. PMID: 21064165
- Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain. | Chen, Z., et al. 2012. J Biol Chem. 287: 25490-500. PMID: 22661716
- Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF. | Scott, DW., et al. 2016. Mol Biol Cell. 27: 1420-30. PMID: 26985018
- p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation. | Singh, NK., et al. 2017. J Biol Chem. 292: 14080-14091. PMID: 28655771
- p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. | Kozasa, T., et al. 1998. Science. 280: 2109-11. PMID: 9641915
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RhoGEF p115 Antibody (YN-12) | sc-81901 | 100 µg/ml | $339.00 |