RGS9 Antibody (C-8): sc-377252

RGS9 Antibody (C-8) is a mouse monoclonal IgM antibody that detects RGS9 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RGS9 antibody (C-8) is available as the non-conjugated form. RGS9 plays a crucial role in regulating G protein signaling pathways, particularly in the central nervous system, where RGS9 is involved in modulating neurotransmitter signaling and neuronal excitability. RGS9 is primarily located in the cytosol, where RGS9 forms complexes with Gβ5 subunits, which are essential for function as a GTPase-activating protein (GAP). Cytosolic localization of RGS9 allows for rapid and efficient regulation of Gαo subunits, thereby influencing downstream signaling events vital for proper neuronal function. Dysregulation of RGS9 has been implicated in various neurological disorders, making RGS9 an important target for research into therapeutic interventions. Through modulation of G protein signaling, RGS9 is essential for maintaining the balance of excitatory and inhibitory signals in the brain, highlighting RGS9′s importance in both normal physiology and disease states.

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RGS9 Antibody (C-8) References:

1. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.  |  Snow, BE., et al. 1999. Proc Natl Acad Sci U S A. 96: 6489-94. PMID: 10339615
2. A G-protein signaling network mediated by an RGS protein.  |  Guan, KL. and Han, M. 1999. Genes Dev. 13: 1763-7. PMID: 10421628
3. Emerging roles for RGS proteins in cell signalling.  |  Hepler, JR. 1999. Trends Pharmacol Sci. 20: 376-82. PMID: 10462761
4. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.  |  Posner, BA., et al. 1999. J Biol Chem. 274: 31087-93. PMID: 10521509
5. RGS9-1 phosphorylation and Ca2+.  |  Wensel, TG. 2002. Adv Exp Med Biol. 514: 125-9. PMID: 12596919
6. Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.  |  Xu, H., et al. 2004. Synapse. 52: 209-17. PMID: 15065220
7. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma.  |  Valdmanis, PN., et al. 2015. Oncogene. 34: 94-103. PMID: 24317514
8. Dysregulation of cancer genes by recurrent intergenic fusions.  |  Yun, JW., et al. 2020. Genome Biol. 21: 166. PMID: 32631391
9. Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study.  |  Beyer, AL., et al. 2022. Int J Mol Sci. 23: PMID: 36362289
10. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
11. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum.  |  Thomas, EA., et al. 1998. J Neurosci Res. 52: 118-24. PMID: 9556034
12. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.  |  Snow, BE., et al. 1998. Proc Natl Acad Sci U S A. 95: 13307-12. PMID: 9789084

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGS9 Antibody (C-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RGS9 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGS9 Antibody (C-8) Specifications

Alternate Product Name: RGS9

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 449-487

Epitope Target: RGS9

Epitope Species: mouse

Product Reactivity/Detection: RGS9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RGS9 Antibody (C-8): P: Blocking Peptide