RGS11 Antibody (E-3): sc-515412
- RGS11 Antibody (E-3) is a mouse monoclonal IgG2b κ RGS11 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 436-457 at the C-terminus of RGS11 of human origin
- RGS11 Antibody (E-3) is recommended for detection of RGS11 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-RGS11 Antibody (E-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RGS11 Antibody (E-3). This work is in progress.
RGS11 Antibody (E-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects RGS11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-RGS11 antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RGS11 plays a crucial role in regulating G protein signaling pathways, particularly in the central nervous system, where RGS11 is involved in modulating neuronal signaling and synaptic transmission. RGS11 is part of a subfamily of RGS proteins that contain a GGL domain, which is essential for binding to Gβ5 subunits, forming active GTPase-activating protein complexes that primarily localize to the cytosol. These complexes are particularly important as RGS11 preferentially targets the Gαo subunit for hydrolysis, thereby inhibiting Gβ1γ2-mediated activation of phospholipase C, which is vital for various cellular responses. RGS11 (E-3) monoclonal antibody serves as an invaluable tool for researchers studying G protein signaling pathways and their implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RGS11 Antibody (E-3) References:
- Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. | Snow, BE., et al. 1999. Proc Natl Acad Sci U S A. 96: 6489-94. PMID: 10339615
- A G-protein signaling network mediated by an RGS protein. | Guan, KL. and Han, M. 1999. Genes Dev. 13: 1763-7. PMID: 10421628
- Emerging roles for RGS proteins in cell signalling. | Hepler, JR. 1999. Trends Pharmacol Sci. 20: 376-82. PMID: 10462761
- Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. | Posner, BA., et al. 1999. J Biol Chem. 274: 31087-93. PMID: 10521509
- Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. | Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
- RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum. | Thomas, EA., et al. 1998. J Neurosci Res. 52: 118-24. PMID: 9556034
- A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. | Snow, BE., et al. 1998. Proc Natl Acad Sci U S A. 95: 13307-12. PMID: 9789084
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RGS11 Antibody (E-3) | sc-515412 | 200 µg/ml | $322.00 | |||
RGS11 Antibody (E-3) AC | sc-515412 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RGS11 Antibody (E-3) HRP | sc-515412 HRP | 200 µg/ml | $322.00 | |||
RGS11 Antibody (E-3) FITC | sc-515412 FITC | 200 µg/ml | $336.00 | |||
RGS11 Antibody (E-3) PE | sc-515412 PE | 200 µg/ml | $349.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 488 | sc-515412 AF488 | 200 µg/ml | $364.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 546 | sc-515412 AF546 | 200 µg/ml | $364.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 594 | sc-515412 AF594 | 200 µg/ml | $364.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 647 | sc-515412 AF647 | 200 µg/ml | $364.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 680 | sc-515412 AF680 | 200 µg/ml | $364.00 | |||
RGS11 Antibody (E-3) Alexa Fluor® 790 | sc-515412 AF790 | 200 µg/ml | $364.00 | |||
RGS11 (E-3) Neutralizing Peptide | sc-515412 P | 100 µg/0.5 ml | $69.00 |