RGMc Antibody (C20): sc-517447

RGMc Antibody (C20) is a mouse monoclonal IgG2b kappa light chain antibody that detects the RGMc protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-RGMc antibody (C20) is available as a non-conjugated format. The repulsive guidance molecule (RGM) family plays a crucial role in the development of the nervous system, particularly in the guidance of growth cones during neuronal development. RGMc, also known as Hemojuvelin, is integral to the signaling pathway that activates hepcidin, a key regulator of iron homeostasis in the body. By working in concert with hepcidin, RGMc helps to restrict iron absorption in the gut, which is vital for maintaining appropriate iron levels and preventing conditions such as iron overload. Defects in the gene encoding RGMc can lead to juvenile hemochromatosis, an autosomal recessive disorder characterized by excessive iron accumulation in the body, highlighting the importance of RGMc in both iron metabolism and overall health. The RGM proteins, including RGMc, are anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor, which is essential for their function and interaction with other proteins. RGMc monoclonal antibody (C20) is a valuable tool for researchers studying the roles of RGM proteins in neuronal development and iron regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RGMc Antibody (C20) References:

1. Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.  |  Oldekamp, J., et al. 2004. Gene Expr Patterns. 4: 283-8. PMID: 15053976
2. Neogenin mediates the action of repulsive guidance molecule.  |  Rajagopalan, S., et al. 2004. Nat Cell Biol. 6: 756-62. PMID: 15258590
3. RGM and its receptor neogenin regulate neuronal survival.  |  Matsunaga, E., et al. 2004. Nat Cell Biol. 6: 749-55. PMID: 15258591
4. Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development.  |  Matsunaga, E. and Chédotal, A. 2004. Dev Growth Differ. 46: 481-6. PMID: 15610137

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RGMc Antibody (C20) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RGMc Antibody (C20) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RGMc Antibody (C20) Specifications

Alternate Product Name: RGMc

Product Clone Name: C20

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 234-416

Epitope Target: RGMc

Epitope Species: human

Product Reactivity/Detection: RGMc

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RGMc Antibody (C20): N/A