RF9 (CAS 876310-60-0)
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RF9 is a small molecule compound that functions as a potent and selective antagonist of the neuropeptide FF receptor 2 (NPFF2). It exerts its mechanism of action by binding to the NPFF2 receptor and blocking the binding of neuropeptide FF (NPFF), thereby inhibiting the downstream signaling pathways activated by NPFF. This interference with NPFF signaling modulates various physiological processes, including pain perception, stress response, and opioid tolerance. In experimental applications, RF9 serves is useful for investigating the specific functions of the NPFF2 receptor and its involvement in various biological pathways, contributing to a deeper understanding of neuropeptide signaling and its potential implications in physiological regulation.
RF9 (CAS 876310-60-0) References
- RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. | Simonin, F., et al. 2006. Proc Natl Acad Sci U S A. 103: 466-71. PMID: 16407169
- Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. | Fang, Q., et al. 2008. Regul Pept. 147: 45-51. PMID: 18276024
- Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. | Pineda, R., et al. 2010. Endocrinology. 151: 1902-13. PMID: 20160130
- Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice. | Moulédous, L., et al. 2010. Neuropeptides. 44: 453-6. PMID: 20554321
- Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice. | Wang, YQ., et al. 2011. Peptides. 32: 702-6. PMID: 21167893
- Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. | Elhabazi, K., et al. 2012. Br J Pharmacol. 165: 424-35. PMID: 21718302
- Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration. | Maletínská, L., et al. 2013. Brain Res. 1498: 33-40. PMID: 23291266
- RF9 excitation of GnRH neurons is dependent upon Kiss1r in the adult male and female mouse. | Liu, X. and Herbison, AE. 2014. Endocrinology. 155: 4915-24. PMID: 25322463
- The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction. | Wahab, F., et al. 2015. J Endocrinol. 225: R49-66. PMID: 25957191
- RF9: May it be a new therapeutic option for hypogonadotropic hypogonadism? | Sahin, Z. and Kelestimur, H. 2019. Med Hypotheses. 128: 54-57. PMID: 31203909
- Kisspeptin and RF9 prevent paroxetine-induced changes in some parameters of seminal vesicle fluid in the male rats. | Gulcu Bulmus, F., et al. 2020. Andrologia. 52: e13538. PMID: 32052480
- Identification of Rf9, a Gene Contributing to the Genetic Complexity of Fertility Restoration in Hybrid Wheat. | Shahinnia, F., et al. 2020. Front Plant Sci. 11: 577475. PMID: 33362809
- RF9 Rescues Cortisol-Induced Repression of Testosterone Levels in Adult Male Macaques. | Ullah, R., et al. 2021. Front Physiol. 12: 630796. PMID: 33716777
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RF9, 1 mg | sc-253428 | 1 mg | $150.00 |