resistin-like α Antibody (R-18): sc-80324
- resistin-like α Antibody (R-18) is a rat monoclonal IgG2a resistin-like α antibody provided at 100 µg/ml
- raised against full length recombinant resistin-like α of mouse origin
- recommended for detection of resistin-like α of mouse origin by WB and ELISA; non cross-reactive with resistin-like β
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for resistin-like α Antibody (R-18). This work is in progress.
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Resistin-like α Antibody (R-18) is a rat monoclonal IgG2a antibody that detects resistin-like alpha (RELM-α) of mouse origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-resistin-like alpha antibody (R-18) is available as a non-conjugated format. RELM-α plays a crucial role in metabolic regulation, particularly in obesity and insulin resistance, making RELM-α an important target for research into diabetes and related metabolic disorders. RELM-α is primarily secreted by adipose tissue and influences inflammatory processes and energy homeostasis. RELM-α′s unique structure, characterized by high cysteine and serine content, allows for disulfide bond formation essential for stability and function. A cysteine repeat motif in RELM-α facilitates interactions with other proteins and signaling pathways involved in metabolic regulation. Understanding RELM-α′s function and interactions can provide valuable insights into mechanisms linking obesity to insulin resistance, highlighting RELM-α′s importance in metabolic disease research.
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resistin-like α Antibody (R-18) References:
- Diabetes. The missing link with obesity? | Flier, JS. 2001. Nature. 409: 292-3. PMID: 11201721
- The hormone resistin links obesity to diabetes. | Steppan, CM., et al. 2001. Nature. 409: 307-12. PMID: 11201732
- A family of tissue-specific resistin-like molecules. | Steppan, CM., et al. 2001. Proc Natl Acad Sci U S A. 98: 502-6. PMID: 11209052
- A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. | Kim, KH., et al. 2001. J Biol Chem. 276: 11252-6. PMID: 11278254
- Regulation of fasted blood glucose by resistin. | Banerjee, RR., et al. 2004. Science. 303: 1195-8. PMID: 14976316
- The current biology of resistin. | Steppan, CM. and Lazar, MA. 2004. J Intern Med. 255: 439-47. PMID: 15049878
- Disulfide-dependent multimeric assembly of resistin family hormones. | Patel, SD., et al. 2004. Science. 304: 1154-8. PMID: 15155948
- Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. | Vendrell, J., et al. 2004. Obes Res. 12: 962-71. PMID: 15229336
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
resistin-like α Antibody (R-18) | sc-80324 | 100 µg/ml | $322.00 |