Rent3a Antibody (PL-B10): sc-134427
- Rent3a Antibody (PL-B10) is a mouse monoclonal IgG2a κ Rent3a antibody provided at 100 µg/ml
- raised against recombinant Rent3a protein of human origin
- recommended for detection of Rent3a of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rent3a Antibody (PL-B10). This work is in progress.
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Rent3a Antibody (PL-B10) is a mouse monoclonal IgG2a kappa light chain antibody that detects Rent3a protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rent3a antibody (PL-B10) is available as non-conjugated format. Rent3a (PL-B10) antibody recognizes a protein crucial in nonsense-mediated RNA decay (NMD), maintaining cellular integrity by preventing translation of faulty transcripts that could produce truncated or malfunctioning proteins. This mechanism protects eukaryotic cells by detecting and degrading defective RNA transcripts, safeguarding against potential deleterious effects from dominant negative or gain-of-function mutations. Rent3a (PL-B10) monoclonal antibody targets a protein that, along with Rent3b homolog, links splicing events to NMD, ensuring only properly processed mRNA translates into functional proteins. Rent3a interaction with spliced mRNA and proteins like Y14 underscores significance in gene expression regulation and cellular homeostasis. Rent3a function remains essential for understanding RNA metabolism complexities and implications in cancer and genetic disorders.
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Rent3a Antibody (PL-B10) References:
- SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. | Page, MF., et al. 1999. Mol Cell Biol. 19: 5943-51. PMID: 10454541
- Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. | Bhattacharya, A., et al. 2000. RNA. 6: 1226-35. PMID: 10999600
- Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. | Mendell, JT., et al. 2000. Mol Cell Biol. 20: 8944-57. PMID: 11073994
- Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). | Serin, G., et al. 2001. Mol Cell Biol. 21: 209-23. PMID: 11113196
- Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability. | Medghalchi, SM., et al. 2001. Hum Mol Genet. 10: 99-105. PMID: 11152657
- Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. | Kim, VN., et al. 2001. Science. 293: 1832-6. PMID: 11546873
- Mammalian orthologues of a yeast regulator of nonsense transcript stability. | Perlick, HA., et al. 1996. Proc Natl Acad Sci U S A. 93: 10928-32. PMID: 8855285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rent3a Antibody (PL-B10) | sc-134427 | 100 µg/ml | $339.00 |