Renin Antibody (G-7): sc-365484
- Renin Antibody (G-7) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 233-263 within an internal region of Renin of mouse origin
- recommended for detection of precursor and mature heavy chain Renin of mouse, rat and human origin by WB, IP, IF and ELISA
- See Renin (B-12): sc-133145 for Renin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Renin Antibody (G-7) for WB applications. These reagents are now offered in bundles with Renin Antibody (G-7) (see ordering information below).
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Renin Antibody (G-7) is a mouse monoclonal IgG2b light chain antibody that detects Renin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Renin antibody (G-7) plays a crucial role in studying the Renin-Angiotensin system (RAS), which is vital for maintaining blood pressure and fluid balance in the body. Renin, a highly specific endopeptidase, is primarily synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus of the kidney, where Renin catalyzes the conversion of angiotensinogen to Angiotensin I. This process is essential as Angiotensin II, produced from Angiotensin I by angiotensin-converting enzyme I, is a potent vasoconstrictor that significantly influences blood pressure regulation and electrolyte balance. Renin expression in other tissues, including the brain, suggests potential roles beyond traditional function, although these are still being explored. Understanding Renin dynamics and interactions within RAS is critical for developing therapeutic strategies for hypertension and related cardiovascular diseases.
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Renin Antibody (G-7) References:
- Aldosterone and renin in essential hypertension. | Genest, J., et al. 1975. Can Med Assoc J. 113: 421-31. PMID: 1098756
- Purification of renin and prorenin. | Inagami, T. 1991. Hypertension. 18: 241-51. PMID: 1889839
- Biochemical properties of renin and prorenin binding to the (pro)renin receptor. | Nabi, AH. and Suzuki, F. 2010. Hypertens Res. 33: 91-7. PMID: 19942927
- Control of renin secretion from kidneys with renin cell hyperplasia. | Kurt, B., et al. 2014. Am J Physiol Renal Physiol. 306: F327-32. PMID: 24285498
- Renin inhibition: immunological procedures and renin inhibitor peptides. | Corvol, P. and Menard, J. 1989. Fundam Clin Pharmacol. 3: 347-62. PMID: 2680848
- Cellular control of renin secretion. | Kurtz, A. 1989. Rev Physiol Biochem Pharmacol. 113: 1-40. PMID: 2697067
- Potential effects of renin activation on the regulation of renin production. | Hsueh, WA. 1984. Am J Physiol. 247: F205-12. PMID: 6087677
- Renin and renin mRNA in proximal tubules of the rat kidney. | Chen, M., et al. 1994. J Clin Invest. 94: 237-43. PMID: 8040265
- Pathophysiology of low renin syndromes: sites of renal renin secretory impairment and prorenin overexpression. | Lush, DJ., et al. 1993. Kidney Int. 43: 983-99. PMID: 8510398
- Cellular control of renin secretion. | Kurtz, A. and Wagner, C. 1999. J Exp Biol. 202: 219-25. PMID: 9882634
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Renin Antibody (G-7) | sc-365484 | 200 µg/ml | $316.00 | |||
Renin Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-535209 | 200 µg Ab; 40 µg BP | $354.00 | |||
Renin Antibody (G-7): m-IgG2b BP-HRP Bundle | sc-549363 | 200 µg Ab; 10 µg BP | $354.00 | |||
Renin (G-7) Neutralizing Peptide | sc-365484 P | 100 µg/0.5 ml | $68.00 |