REM2 Antibody (C-11): sc-514999
- REM2 Antibody (C-11) is a mouse monoclonal IgG1 κ REM2 antibody provided at 200 µg/ml
- raised against amino acids 129-165 mapping within an internal region of REM2 of human origin
- REM2 Antibody (C-11) is recommended for detection of REM2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-REM2 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for REM2 Antibody (C-11) for WB applications. This reagent is now offered in a bundle with REM2 Antibody (C-11) (see ordering information below).
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REM2 (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects REM2 protein of mouse, rat and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). REM2 (C-11) antibody is available as both non-conjugated form, as well as multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC) and multiple Alexa Fluor® conjugates. REM2 (RAS (RAD and GEM)-like GTP binding 2) is a 340 amino acid cell membrane protein that functions as a GTPase and belongs to the RGK family as well as the small GTPase superfamily. A suppressor of the p53 pathway, REM2 also mediates the fibroblastic growth factor 2 (FGF-2) signaling pathway and is involved in maintaining the proliferation of human embryonic stem cells. Expressed in kidney and brain, REM2 is encoded by a gene that maps to human chromosome 14q11.2. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer′s disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
REM2 Antibody (C-11) References:
- Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. | Finlin, BS., et al. 2000. Biochem J. 347 Pt 1: 223-31. PMID: 10727423
- Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms. | Avramopoulos, D., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 132B: 9-13. PMID: 15389761
- Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. | Finlin, BS., et al. 2005. J Biol Chem. 280: 41864-71. PMID: 15728182
- An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis. | Bierings, R., et al. 2008. J Biol Chem. 283: 4408-16. PMID: 18056257
- Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: an update. | Larner, AJ. and Doran, M. 2009. J Alzheimers Dis. 17: 259-65. PMID: 19221408
- Alpha-1-antitrypsin phenotypes in adult liver disease patients. | Topic, A., et al. 2009. Ups J Med Sci. 114: 228-34. PMID: 19961268
- Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1. | Edel, MJ., et al. 2010. Genes Dev. 24: 561-73. PMID: 20231315
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
REM2 Antibody (C-11) | sc-514999 | 200 µg/ml | $316.00 | |||
REM2 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-531796 | 200 µg Ab; 20 µg BP | $354.00 | |||
REM2 Antibody (C-11) AC | sc-514999 AC | 500 µg/ml, 25% agarose | $416.00 | |||
REM2 Antibody (C-11) HRP | sc-514999 HRP | 200 µg/ml | $316.00 | |||
REM2 Antibody (C-11) FITC | sc-514999 FITC | 200 µg/ml | $330.00 | |||
REM2 Antibody (C-11) PE | sc-514999 PE | 200 µg/ml | $343.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 488 | sc-514999 AF488 | 200 µg/ml | $357.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 546 | sc-514999 AF546 | 200 µg/ml | $357.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 594 | sc-514999 AF594 | 200 µg/ml | $357.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 647 | sc-514999 AF647 | 200 µg/ml | $357.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 680 | sc-514999 AF680 | 200 µg/ml | $357.00 | |||
REM2 Antibody (C-11) Alexa Fluor® 790 | sc-514999 AF790 | 200 µg/ml | $357.00 |