Relaxin Receptor 3 Antibody (D-10): sc-377365

Relaxin Receptor 3 Antibody (D-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Relaxin Receptor 3 (RXFP3) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-RXFP3 antibody (D-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RXFP3, also known as Relaxin/insulin-like family peptide receptor 3, RLN3R1, GPCR135, and SALPR, is a G protein-coupled receptor that plays a crucial role in the central nervous system by binding to Relaxin 3, which is essential for the differentiation and maintenance of neuronal tissues. RXFP3 mediates the central processing of sensory signals and is implicated in modulating stress responses, making RXFP3 a significant target for research in neurobiology and stress-related disorders. RXFP3 is predominantly expressed in the brain, with the highest levels found in the substantia nigra and pituitary gland, followed by the hippocampus, spinal cord, amygdala, caudate nucleus, and corpus callosum, while exhibiting lower expression in the cerebellum. RXFP3 is also present in peripheral tissues, with notable expression in the adrenal glands and lower levels in the pancreas, salivary glands, placenta, mammary glands, and testis.

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Relaxin Receptor 3 Antibody (D-10) References:

1. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.  |  Liu, C., et al. 2003. J Biol Chem. 278: 50754-64. PMID: 14522968
2. Identification of a mouse orthologue of the G-protein-coupled receptor SALPR and its expression in adult mouse brain and during development.  |  Boels, K., et al. 2004. Brain Res Dev Brain Res. 152: 265-8. PMID: 15351514
3. Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species.  |  Chen, J., et al. 2005. J Pharmacol Exp Ther. 312: 83-95. PMID: 15367576
4. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.  |  Liu, C., et al. 2005. Mol Pharmacol. 67: 231-40. PMID: 15465925
5. Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing.  |  Sutton, SW., et al. 2004. Neuroendocrinology. 80: 298-307. PMID: 15677880
6. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.  |  Van der Westhuizen, ET., et al. 2005. Ann N Y Acad Sci. 1041: 332-7. PMID: 15956730
7. G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135.  |  Sutton, SW., et al. 2005. Neuroendocrinology. 82: 139-50. PMID: 16679775
8. Self-medication with sucrose.  |  Ulrich-Lai, YM. 2016. Curr Opin Behav Sci. 9: 78-83. PMID: 26977424
9. Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling.  |  Olucha-Bordonau, FE., et al. 2018. CNS Neurosci Ther. 24: 694-702. PMID: 29722152
10. The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease.  |  Leysen, H., et al. 2022. Int J Mol Sci. 23: PMID: 35457203
11. Mechanisms of biased agonism by Gαi/o-biased stapled peptide agonists of the relaxin-3 receptor.  |  Jayakody, T., et al. 2024. Sci Signal. 17: eabl5880. PMID: 38349968
12. Hypothalamic-hindbrain circuit for consumption-induced fear regulation.  |  Wang, Q., et al. 2024. Nat Commun. 15: 7728. PMID: 39231981

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Relaxin Receptor 3 Antibody (D-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Relaxin Receptor 3 Antibody (D-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Relaxin Receptor 3 Antibody (D-10) Specifications

Alternate Product Name: Relaxin Receptor 3

Product Clone Name: D-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-135

Epitope Target: Relaxin Receptor 3

Epitope Species: human

Product Reactivity/Detection: Relaxin Receptor 3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Relaxin Receptor 3 Antibody (D-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin