Relaxin 1 Antibody (6F1willi): sc-57426

Relaxin 1 Antibody (6F1willi) is a mouse monoclonal IgG1 antibody that detects Relaxin 1 protein of human origin by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). Anti-Relaxin 1 antibody (6F1willi) is available as a non-conjugated format. Relaxin 1, also known as RLXH1, is a crucial peptide hormone produced by the corpora lutea of the ovary during pregnancy in various mammalian species, including humans. Relaxin 1 plays a vital role in the birthing process by promoting the softening and lengthening of the pubic symphysis and cervix, thereby facilitating childbirth. Relaxin 1 has been shown to inhibit uterine contractions, which may influence the timing of parturition. Structurally, Relaxin 1 consists of two peptide chains, A and B, that are covalently linked by disulfide bonds, similar to the structure of insulin. The two peptides are synthesized from a single-chain precursor polypeptide, with the B chain located at the amino-terminus. The gene encoding human Relaxin 1 is located on chromosome 9, and Relaxin 2, a related protein, is also expressed in the ovary during pregnancy, with its gene mapping to the same chromosome. Relaxin 1′s ability to modulate physiological processes during pregnancy underscores its significance in reproductive biology and potential therapeutic applications.

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Relaxin 1 Antibody (6F1willi) References:

1. Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.  |  Masini, E., et al. 2002. Br J Pharmacol. 137: 337-44. PMID: 12237253
2. Relaxin regulation of endometrial structure and function in the rhesus monkey.  |  Goldsmith, LT., et al. 2004. Proc Natl Acad Sci U S A. 101: 4685-9. PMID: 15070778
3. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.  |  Samuel, CS., et al. 2004. Endocrinology. 145: 4125-33. PMID: 15155573
4. Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats.  |  Conrad, KP., et al. 2004. Endocrinology. 145: 3289-96. PMID: 15198972
5. Human relaxin-2: historical perspectives and role in cancer biology.  |  Nair, VB., et al. 2012. Amino Acids. 43: 1131-40. PMID: 22855207
6. Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer.  |  Tevz, G., et al. 2016. Mol Cell Endocrinol. 420: 159-68. PMID: 26499396
7. Circulating Relaxin-1 Level Is a Surrogate Marker of Myocardial Fibrosis in HFrEF.  |  Simon, J., et al. 2019. Front Physiol. 10: 690. PMID: 31231242
8. Cerebral cavernomas in adults and children express relaxin.  |  Gewiss, C., et al. 2020. J Neurosurg Pediatr. 25: 144-150. PMID: 31756710
9. Structure of a genomic clone encoding biologically active human relaxin.  |  Hudson, P., et al. Nature. 301: 628-31. PMID: 6298628
10. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.  |  Hudson, P., et al. 1984. EMBO J. 3: 2333-9. PMID: 6548702
11. Two human relaxin genes are on chromosome 9.  |  Crawford, RJ., et al. 1984. EMBO J. 3: 2341-5. PMID: 6548703
12. Molecular cloning and characterization of cDNA sequences coding for rat relaxin.  |  Hudson, P., et al. 1981. Nature. 291: 127-31. PMID: 7231533

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Relaxin 1 Antibody (6F1willi) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Relaxin 1 Antibody (6F1willi) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Relaxin 1 Antibody (6F1willi) Specifications

Alternate Product Name: Relaxin 1

Product Clone Name: 6F1willi

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Relaxin 1

Epitope Species: human

Product Reactivity/Detection: Relaxin 1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Relaxin 1 Antibody (6F1willi): N/A