Relaxin 1/2 Antibody (8H11kurd): sc-57424

Relaxin 1/2 Antibody (8H11kurd) is a mouse monoclonal IgG1 antibody that detects Relaxin 1/2 of human origin by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). Anti-Relaxin 1/2 antibody (8H11kurd) is available as the non-conjugated format. Relaxin 1, also known as RLXH1, is a crucial peptide hormone produced by the corpora lutea of the ovary during pregnancy in various mammalian species, including humans. Relaxin 1 plays a vital role in the birthing process by promoting the softening and lengthening of the pubic symphysis and cervix, thereby facilitating childbirth. Relaxin 1 has been shown to inhibit uterine contractions, which may influence the timing of parturition. Structurally, Relaxin 1 consists of two peptide chains, A and B, that are covalently linked by disulfide bonds, similar to the structure of insulin. The two peptides are synthesized from a single-chain precursor polypeptide, with the B chain located at the amino-terminus. The gene encoding human Relaxin 1 is located on chromosome 9, and Relaxin 2, a related protein, is also expressed in the ovary during pregnancy, with its gene mapping to the same chromosome. Relaxin 1′s ability to modulate reproductive processes underscores its significance in reproductive biology and potential therapeutic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Relaxin 1/2 Antibody (8H11kurd) References:

1. Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway.  |  Masini, E., et al. 2002. Br J Pharmacol. 137: 337-44. PMID: 12237253
2. Relaxin regulation of endometrial structure and function in the rhesus monkey.  |  Goldsmith, LT., et al. 2004. Proc Natl Acad Sci U S A. 101: 4685-9. PMID: 15070778
3. Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.  |  Samuel, CS., et al. 2004. Endocrinology. 145: 4125-33. PMID: 15155573
4. Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats.  |  Conrad, KP., et al. 2004. Endocrinology. 145: 3289-96. PMID: 15198972
5. Structure of a genomic clone encoding biologically active human relaxin.  |  Hudson, P., et al. Nature. 301: 628-31. PMID: 6298628
6. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.  |  Hudson, P., et al. 1984. EMBO J. 3: 2333-9. PMID: 6548702
7. Two human relaxin genes are on chromosome 9.  |  Crawford, RJ., et al. 1984. EMBO J. 3: 2341-5. PMID: 6548703
8. Molecular cloning and characterization of cDNA sequences coding for rat relaxin.  |  Hudson, P., et al. 1981. Nature. 291: 127-31. PMID: 7231533

The preferred Relaxin 1 antibody is Relaxin 1 Antibody (6F1willi): sc-57426.