Reg IV Antibody (Lc07): sc-80320
- Reg IV Antibody (Lc07) is a mouse monoclonal IgG2b Reg IV antibody, cited in 1 publications, provided at 100 µg/ml
- raised against full length recombinant Reg IV of human origin
- recommended for detection of Reg IV of human origin by WB and ELISA; non cross-reactive with Reg Iβ
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Reg IV Antibody (Lc07). This work is in progress.
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Reg IV Antibody (Lc07) is a mouse monoclonal IgG2b antibody that detects the Reg IV protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Reg IV antibody (Lc07) is available as a non-conjugated format. Reg IV protein, a member of the regenerating gene family within the C-type lectin superfamily, plays a crucial role in cell proliferation and differentiation in various tissues, including the liver, pancreas, stomach, and intestines. This 158-amino acid secretory protein is particularly significant due to involvement in cell regeneration and survival, exhibiting a notable growth-stimulating effect on pancreatic beta cells, which are essential for insulin production and glucose regulation. Reg IV is highly expressed in several cancers, including colorectal, gastric, and prostate cancers, where Reg IV-positive tumor cells can exhibit diverse phenotypes such as mucus-secreting, enterocyte-like, and undifferentiated forms. Anti-Reg IV antibody (Lc07) influences tumor cell behavior, underscoring potential as a biomarker for cancer progression and a target for therapeutic strategies.
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Reg IV Antibody (Lc07) References:
- Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. | Violette, S., et al. 2003. Int J Cancer. 103: 185-93. PMID: 12455032
- REG gene expression is associated with the infiltrating growth of gastric carcinoma. | Yonemura, Y., et al. 2003. Cancer. 98: 1394-400. PMID: 14508825
- Overexpression of Reg IV in colorectal adenoma. | Zhang, Y., et al. 2003. Cancer Lett. 200: 69-76. PMID: 14550954
- Reg gene family and human diseases. | Zhang, YW., et al. 2003. World J Gastroenterol. 9: 2635-41. PMID: 14669303
- [Over expression of Reg IV in peritoneal dissemination of gastric cancer]. | Miyagawa, K., et al. 2004. Gan To Kagaku Ryoho. 31: 1909-11. PMID: 15553756
- Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. | Nata, K., et al. 2004. Gene. 340: 161-70. PMID: 15556304
- Reg IV: a promising marker of hormone refractory metastatic prostate cancer. | Gu, Z., et al. 2005. Clin Cancer Res. 11: 2237-43. PMID: 15788672
- High expression of RELP (Reg IV) in neoplastic goblet cells of appendiceal mucinous cystadenoma and pseudomyxoma peritonei. | Heiskala, K., et al. 2006. Virchows Arch. 448: 295-300. PMID: 16323007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reg IV Antibody (Lc07) | sc-80320 | 100 µg/ml | $322.00 |