REEP6 Antibody (B-12): sc-374167

REEP6 Antibody (B-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects REEP6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-REEP6 antibody (B-12) is available as the non-conjugated form. REEP6, also known as receptor accessory protein 6, DP1L1, or TB2L1, is a 184 amino acid multi-pass membrane protein that plays a crucial role in enhancing the cell surface expression of odorant receptors, which are essential for the sense of smell. This protein is part of the receptor expression enhancing protein (REEP) family, which contains domains that facilitate intracellular trafficking and secretion. The proper localization and function of REEP6 are vital, as they ensure that odorant receptors are effectively presented on the cell surface, thereby influencing olfactory signaling pathways. The gene encoding REEP6 is located on human chromosome 19, a region known for its high gene density and housing numerous immunoglobulin superfamily members, including various receptors that are critical for immune response. REEP6 monoclonal antibody (B-12) can help researchers gain insights into the mechanisms of olfactory receptor expression and its implications in sensory biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

REEP6 Antibody (B-12) References:

1. The DNA sequence and comparative analysis of human chromosome 10.  |  Deloukas, P., et al. 2004. Nature. 429: 375-81. PMID: 15164054
2. RTP family members induce functional expression of mammalian odorant receptors.  |  Saito, H., et al. 2004. Cell. 119: 679-91. PMID: 15550249
3. Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed in retinal ganglion cells.  |  Sato, H., et al. 2005. Invest Ophthalmol Vis Sci. 46: 791-6. PMID: 15728532
4. Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31.  |  Züchner, S., et al. 2006. Am J Hum Genet. 79: 365-9. PMID: 16826527
5. Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism.  |  Castermans, D., et al. 2007. Eur J Hum Genet. 15: 422-31. PMID: 17290275
6. REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31.  |  Beetz, C., et al. 2008. Brain. 131: 1078-86. PMID: 18321925
7. New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP).  |  Hewamadduma, C., et al. 2009. Neurogenetics. 10: 105-10. PMID: 19034539
8. Loss of REEP4 causes paralysis of the Xenopus embryo.  |  Argasinska, J., et al. 2009. Int J Dev Biol. 53: 37-43. PMID: 19123125
9. Receptor expression-enhancing protein 1 gene (SPG31) mutations are rare in Chinese Han patients with hereditary spastic paraplegia.  |  Du, J., et al. 2009. Chin Med J (Engl). 122: 2064-6. PMID: 19781397

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-REEP6 Antibody (B-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-REEP6 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

REEP6 Antibody (B-12) Specifications

Alternate Product Name: REEP6

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 157-169

Epitope Target: REEP6

Epitope Species: human

Product Reactivity/Detection: REEP6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for REEP6 Antibody (B-12): P: Blocking Peptide