RBP1 Antibody (112C4a): sc-81640

RBP1 Antibody (112C4a) is a mouse monoclonal IgG1 antibody that detects RBP1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-RBP1 antibody (112C4a) is available as a non-conjugated format. Retinoblastoma-binding protein 1 (RBP1), also known as RBP-1, RBBP1, or ARID4A (AT-rich interactive domain-containing protein 4A), plays a crucial role in regulating gene expression and cellular processes. RBP1 is primarily located in the nucleus, where RBP1 interacts with retinoblastoma protein (Rb), a key transcriptional regulator involved in cell cycle control and heterochromatin formation. RBP1 interaction with Rb is vital for recruiting chromatin-modifying proteins, which facilitate Rb′s function as a transcriptional repressor of E2F target genes. This regulatory mechanism is essential for maintaining proper cell cycle progression and preventing uncontrolled cell division, which can lead to tumorigenesis. RBP1 can act as a bridging molecule to recruit histone deacetylases (HDACs), further influencing gene expression. RBP1 exists in three isoforms due to alternative splicing, which may contribute to diverse functional roles in cellular processes.

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RBP1 Antibody (112C4a) References:

1. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.  |  Lai, A., et al. 2001. Mol Cell Biol. 21: 2918-32. PMID: 11283269
2. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.  |  Meehan, WJ., et al. 2004. J Biol Chem. 279: 1562-9. PMID: 14581478
3. Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.  |  Chen, YF., et al. 2003. DNA Cell Biol. 22: 657-64. PMID: 14611687
4. RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence.  |  Binda, O., et al. 2006. Mol Cell Biol. 26: 1917-31. PMID: 16479010
5. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements.  |  Monroe, DG., et al. 2006. J Biol Chem. 281: 28596-604. PMID: 16873370
6. Deficiency of Rbbp1/Arid4a and Rbbp1l1/Arid4b alters epigenetic modifications and suppresses an imprinting defect in the PWS/AS domain.  |  Wu, MY., et al. 2006. Genes Dev. 20: 2859-70. PMID: 17043311

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RBP1 Antibody (112C4a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RBP1 Antibody (112C4a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RBP1 Antibody (112C4a) Specifications

Alternate Product Name: RBP1

Product Clone Name: 112C4a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: RBP1

Epitope Species: human

Product Reactivity/Detection: RBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RBP1 Antibody (112C4a): N/A