RBMXL2 Antibody (RR-17): sc-101134

RBMXL2 Antibody (RR-17) is a mouse monoclonal IgG1 kappa light chain antibody that detects RBMXL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-RBMXL2 antibody (RR-17) is available as a non-conjugated format. RBMXL2, also known as RNA binding motif protein, X-linked-like 2, plays a crucial role in gene expression regulation during spermatogenesis, particularly in meiotic spermatocytes where RBMXL2 is predominantly expressed. RBMXL2 is localized in the nucleus and contains one RNA recognition motif (RRM), which is essential for RBMXL2′s function as a splicing regulator specific to germ cells. RBMXL2′s ability to interact with pre-mRNA and facilitate processing is vital for mature mRNA production, necessary for proper sperm development. Disruptions in RBMXL2 function can lead to autosomal male infertility, highlighting RBMXL2′s importance in reproductive biology. RBMXL2 is part of a larger family of heterogeneous nuclear ribonucleoproteins (hnRNPs), which are integral to mRNA transcription, processing, and transport, making RBMXL2 (RR-17) antibody a valuable tool for researchers studying gene regulation and fertility.

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RBMXL2 Antibody (RR-17) References:

1. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.  |  Melcák, I., et al. 2000. Mol Biol Cell. 11: 497-510. PMID: 10679009
2. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.  |  Elliott, DJ., et al. 2000. Hum Mol Genet. 9: 2117-24. PMID: 10958650
3. Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men.  |  Maymon, BB., et al. 2002. Acta Histochem. 104: 255-61. PMID: 12389739
4. The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.  |  Elliott, DJ. 2004. Int J Androl. 27: 328-34. PMID: 15595951
5. An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.  |  Ehrmann, I., et al. 2019. Elife. 8: PMID: 30674417
6. Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases.  |  Aldalaqan, S., et al. 2022. Cell Cycle. 21: 219-227. PMID: 34927545
7. Cryptic splice site poisoning and meiotic arrest caused by a homozygous frameshift mutation in RBMXL2: A case report.  |  Ghieh, F., et al. 2022. Andrologia. 54: e14595. PMID: 36102209
8. The Role of Placental DNA Methylation at Reproduction-Related Genes in Associations between Prenatal Bisphenol Analogues Exposure and the Digit Ratio in Children at Age 4: A Birth Cohort Study.  |  Chen, J., et al. 2024. Environ Sci Technol. 58: 11320-11330. PMID: 38898774
9. Isolation and characterization of a novel, low abundance hnRNP protein: A0.  |  Myer, VE. and Steitz, JA. 1995. RNA. 1: 171-82. PMID: 7585247
10. A nuclear localization domain in the hnRNP A1 protein.  |  Siomi, H. and Dreyfuss, G. 1995. J Cell Biol. 129: 551-60. PMID: 7730395
11. Identification and characterisation of a novel human RNA-binding protein.  |  Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
12. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.  |  Hanamura, A., et al. 1998. RNA. 4: 430-44. PMID: 9630249

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RBMXL2 Antibody (RR-17) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RBMXL2 Antibody (RR-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RBMXL2 Antibody (RR-17) Specifications

Alternate Product Name: RBMXL2

Product Clone Name: RR-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: RBMXL2

Epitope Species: human

Product Reactivity/Detection: RBMXL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RBMXL2 Antibody (RR-17): N/A