Rap1 Antibody (A-8): sc-166556
- Rap1 Antibody (A-8) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 528-827 of Rap1 of Saccharomyces cerevisiae origin
- recommended for detection of Rap1 of y origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rap1 Antibody (A-8) for WB applications. These reagents are now offered in bundles with Rap1 Antibody (A-8) (see ordering information below).
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Rap1 Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects RAP1 in various species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-RAP1 antibody (A-8) recognizes RAP1, also known as TERF2IP or DRIP5, a 399 amino acid protein located in both the nucleus and cytoplasm, which plays a crucial role in maintaining telomere integrity and regulating transcription. RAP1 contains one BRCT domain and one Myb-like domain, which are essential for telomere protection and gene expression regulation. RAP1 is recruited to telomeric double-stranded 5′-TTAGGG-3′ repeats through interaction with TRF2, highlighting RAP1′s importance in telomere biology. RAP1 functions as a negative regulator of telomere recombination and represses homology-directed repair, processes critical for maintaining telomere length and genomic stability. RAP1′s gene is located on human chromosome 16q23.1 and mouse chromosome 8 E1, underscoring evolutionary conservation and significance across species.
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Rap1 Antibody (A-8) References:
- RAP1-GTPase signaling and platelet function. | Stefanini, L. and Bergmeier, W. 2016. J Mol Med (Berl). 94: 13-9. PMID: 26423530
- The Mystery of Rap1 Suppression of Oncogenic Ras. | Nussinov, R., et al. 2020. Trends Cancer. 6: 369-379. PMID: 32249186
- Rap1 in the VMH regulates glucose homeostasis. | Kaneko, K., et al. 2021. JCI Insight. 6: PMID: 33974562
- RAP1 moonlights to activate NF-κB and Notch in ALT. | Churikov, D. and Géli, V. 2021. Sci Signal. 14: PMID: 34187904
- RAP1/TERF2IP-A Multifunctional Player in Cancer Development. | Deregowska, A. and Wnuk, M. 2021. Cancers (Basel). 13: PMID: 34885080
- The Connection Between Rap1 and Talin1 in the Activation of Integrins in Blood Cells. | Sun, H., et al. 2022. Front Cell Dev Biol. 10: 908622. PMID: 35721481
- Rap1 in the Context of PCSK9, Atherosclerosis, and Diabetes. | Agarwal, H., et al. 2023. Curr Atheroscler Rep. 25: 931-937. PMID: 37979063
- Unwrap RAP1's Mystery at Kinetoplastid Telomeres. | Li, B. 2024. Biomolecules. 14: PMID: 38254667
- Presynaptic structural and functional plasticity are coupled by convergent Rap1 signaling. | Kim, YD., et al. 2024. J Cell Biol. 223: PMID: 38748250
- Rap1 Brings the A Game to Control Lung Endothelium. | Martín-Aragón Baudel, M., et al. 2024. Arterioscler Thromb Vasc Biol. 44: 2288-2290. PMID: 39441913
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rap1 Antibody (A-8) | sc-166556 | 200 µg/ml | $322.00 | |||
Rap1 Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-540121 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rap1 Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-541916 | 200 µg Ab; 20 µg BP | $361.00 |