RANKL Antibody (12A380): sc-59982

RANKL Antibody (12A380) is a mouse monoclonal IgG1 antibody raised against amino acids 1-317 of RANKL of mouse origin, effectively detecting RANKL proteins from mouse, rat, and human origins by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). RANKL, also known as Receptor Activator of Nuclear Factor Kappa-B Ligand, TNFSF11, TRANCE, OPGL, or ODF, is a type II transmembrane protein primarily expressed on the surface of osteoblasts, stromal cells, and activated T cells. RANKL (12A380) antibody localizes to the cell membrane, which is crucial for facilitating cell-to-cell interactions, particularly the binding to RANK receptor on osteoclast precursors and dendritic cells. This membrane-bound interaction activates essential signaling pathways such as NF-κB and JNK, leading to osteoclast differentiation and activation, which are vital for bone remodeling and immune system regulation. Dysregulation of RANKL expression or function can result in pathological conditions like osteoporosis, rheumatoid arthritis, and bone metastasis, underscoring its importance in maintaining skeletal integrity and immune homeostasis. RANKL monoclonal antibody (12A380) can advance the understanding of bone metabolism disorders and immune-related diseases, aiding in the development of therapeutic interventions. Anti-RANKL antibody (12A380) serves as an essential resource for studies involving osteoclast biology, T cell regulation, and related pathological conditions.

The preferred RANKL antibody is RANKL Antibody (12A668): sc-52950.