RANK Antibody (9A725): sc-52951
- RANK Antibody (9A725) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 100 µg/ml
- raised against amino acids 326-616 of RANK of human origin
- recommended for detection of RANK of human origin by WB, IF, IHC(P) and FCM
- See RANK (H-7): sc-374360 for RANK antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RANK Antibody (9A725). This work is in progress.
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RANK Antibody (9A725) is a mouse monoclonal IgG1 antibody that detects RANK in human samples through various applications including western blotting (WB), immunofluorescence (IF), immunoprecipitation with paraffin-embedded sections (IHCP), and flow cytometry (FCM). RANK, or receptor activator of NFκB, plays a crucial role in the immune system and bone metabolism by mediating the interaction between osteoclasts and their precursors, which is essential for bone resorption and remodeling. This type I membrane receptor is predominantly expressed on dendritic cells and is vital for the activation of NFκB and JNK signaling pathways, which are important for cell survival and proliferation. The C-terminus of RANK is particularly significant as RANK (9A725) antibody binds to TRAF2, TRAF5, and TRAF6, thereby facilitating the downstream signaling necessary for immune responses. Additionally, RANK interacts with RANKL, a type II transmembrane protein primarily found in lymphoid tissues and T cell lines, highlighting RANK′s importance in regulating T cell activity and osteoclast differentiation. Anti-RANK antibody (9A725) is an invaluable tool for researchers studying the mechanisms of immune regulation and bone health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RANK Antibody (9A725) | sc-52951 | 100 µg/ml | $333.00 |