RANK Antibody (64C1385.1): sc-59981
- RANK Antibody (64C1385.1) is a mouse monoclonal IgG1, cited in 6 publications, provided at 50 µg/0.5 ml
- raised against the extracellular domain of RANK of human origin
- recommended for detection of RANK of mouse, rat and human origin by WB, IP and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- See RANK (H-7): sc-374360 for RANK antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RANK Antibody (64C1385.1). This work is in progress.
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RANK Antibody (64C1385.1) is a mouse monoclonal IgG1 antibody that detects RANK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). RANK, or receptor activator of NFκB, plays a crucial role in the immune system and bone metabolism by mediating the interaction between osteoclasts and their precursors, which is essential for bone resorption and remodeling. This type I membrane receptor is predominantly expressed on dendritic cells and is involved in the activation of NFκB and JNK signaling pathways, which are vital for various cellular responses, including inflammation and apoptosis. The C-terminus of RANK facilitates the binding of TRAF2, TRAF5, and TRAF6, which are necessary for the downstream signaling that leads to NFκB activation. Additionally, RANK interacts with RANKL, a type II transmembrane protein primarily found in lymphoid tissues and T cell lines, highlighting RANK′s significance in regulating T cell function and osteoclast differentiation. Anti-RANK antibody (64C1385.1) is an invaluable tool for researchers studying the complex mechanisms of immune response and bone health, providing insights into potential therapeutic targets for diseases such as osteoporosis and rheumatoid arthritis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RANK Antibody (64C1385.1) References:
- RANK-L and RANK: T cells, bone loss, and mammalian evolution. | Theill, LE., et al. 2002. Annu Rev Immunol. 20: 795-823. PMID: 11861618
- Osteoclast precursors, RANKL/RANK, and immunology. | Xing, L., et al. 2005. Immunol Rev. 208: 19-29. PMID: 16313338
- TRAFs in RANK signaling. | Darnay, BG., et al. 2007. Adv Exp Med Biol. 597: 152-9. PMID: 17633024
- RANK ligand: effects of inhibition. | George, S., et al. 2010. Curr Oncol Rep. 12: 80-6. PMID: 20425591
- Outflanking RANK with a designer antagonist cytokine. | Ou-Yang, CW. and Siegel, RM. 2014. Sci Signal. 7: pe20. PMID: 25140052
- RANKL/RANK control Brca1 mutation-. | Sigl, V., et al. 2016. Cell Res. 26: 761-74. PMID: 27241552
- RANK and EGFR in invasive breast carcinoma. | Papanastasiou, AD., et al. 2017. Cancer Genet. 216-217: 61-66. PMID: 29025596
- RANKL and RANK: From Mammalian Physiology to Cancer Treatment. | Rao, S., et al. 2018. Trends Cell Biol. 28: 213-223. PMID: 29241686
- Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis. | Li, Y., et al. 2019. J Bone Miner Res. 34: 1938-1951. PMID: 31173390
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RANK Antibody (64C1385.1) | sc-59981 | 50 µg/0.5 ml | $316.00 | |||
RANK Antibody (64C1385.1) PE | sc-59981 PE | 100 tests in 2 ml | $343.00 |