Ran BP-3 Antibody (C-5): sc-373678
- Ran BP-3 Antibody (C-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 101-244 mapping within an internal region of Ran BP-3 of human origin
- recommended for detection of Ran BP-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Ran BP-3 Antibody (C-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with Ran BP-3 Antibody (C-5) (see ordering information below).
Ran BP-3 Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects Ran BP-3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ran BP-3 plays a crucial role as a scaffold protein that facilitates the assembly of export complexes, particularly by promoting the binding of Crm1 to RCC1 in the presence of Ran GTP. This interaction is vital for the export of proteins and RNA from the nucleus, a process essential for maintaining cellular function and regulating gene expression. Additionally, Ran BP-3′s ability to bind β-catenin highlights involvement in the inhibition of the Wnt signaling pathway, which is important for various developmental processes and cellular functions. The precise regulation of these interactions underscores the significance of Ran BP-3 in cellular transport mechanisms and potential implications in cancer biology and other diseases. Anti-Ran BP-3 antibody (C-5) serves as an invaluable tool for researchers studying nuclear transport and signaling pathways.
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Ran BP-3 Antibody (C-5) References:
- RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3. | Welch, K., et al. 1999. Mol Cell Biol. 19: 8400-11. PMID: 10567565
- Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. | Nemergut, ME., et al. 2002. J Biol Chem. 277: 17385-8. PMID: 11932251
- AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells. | Lorenzato, A., et al. 2013. Exp Cell Res. 319: 2627-36. PMID: 23948303
- Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection. | Seo, YJ., et al. 2013. PLoS One. 8: e75005. PMID: 24137500
- Crystal structure of importin-α3 bound to the nuclear localization signal of Ran-binding protein 3. | Koyama, M. and Matsuura, Y. 2017. Biochem Biophys Res Commun. 491: 609-613. PMID: 28760339
- Ran-binding protein 3 is associated with human spermatogenesis and male infertility. | Tang, W., et al. 2020. Andrologia. 52: e13446. PMID: 31833110
- Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. | Chernyakov, D., et al. 2021. J Exp Clin Cancer Res. 40: 226. PMID: 34233711
- RanBP3 Regulates Proliferation, Apoptosis and Chemosensitivity of Chronic Myeloid Leukemia Cells via Mediating SMAD2/3 and ERK1/2 Nuclear Transport. | Li, Q., et al. 2021. Front Oncol. 11: 698410. PMID: 34504783
- Comparing the Biology of Young versus Old Age Estrogen-Receptor-Positive Breast Cancer through Gene and Protein Expression Analyses. | Siddig, A., et al. 2023. Biomedicines. 11: PMID: 36672708
- Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport. | Yoon, SO., et al. 2023. Mol Cell. 83: 4190. PMID: 37980093
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ran BP-3 Antibody (C-5) | sc-373678 | 200 µg/ml | $316.00 | |||
Ran BP-3 Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-542695 | 200 µg Ab; 20 µg BP | $354.00 |