Ran BP-17 Antibody (B-1): sc-518249
- Ran BP-17 Antibody (B-1) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 558-580 of Ran BP-17 of human origin
- recommended for detection of Ran BP-17 of human origin by WB, IP, IF and ELISA
- Anti-Ran BP-17 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Ran BP-17 (B-1): sc-518249.
- m-IgG1 BP-HRP is the preferred secondary detection reagent for Ran BP-17 Antibody (B-1) for WB applications. This reagent is now offered in a bundle with Ran BP-17 Antibody (B-1) (see ordering information below).
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Ran BP-17 Antibody (B-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ran BP-17 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Ran BP-17 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Ran BP-17, also known as ran-binding protein 17, is a crucial component in the nuclear transport system, playing a significant role in the import of proteins with a nuclear localization signal (NLS) through nuclear pore complexes (NPCs). This process is vital for cellular function, as nuclear transport regulates the movement of proteins and large RNAs, ensuring essential molecules reach the nucleus to perform their functions. Ran BP-17 consists of 1,088 amino acids and belongs to the importin-beta superfamily of nuclear transport receptors. Ran BP-17 shows predominant expression in the testis, with moderate levels in the pancreas and lower expression in the heart, placenta, lung, liver, thyroid, spinal cord, trachea, and adrenal gland. Ran BP-17 interacts with nucleoporins and the GTP-bound form of Ran to facilitate transport processes. Human Ran BP-16 and Ran BP-17 share 66% amino acid sequence identity, demonstrating evolutionary conservation across species including chimpanzees, dogs, cows, mice, and rats, with Ran BP-17 gene mapping to human chromosome 5q35.1. These characteristics make Ran BP-17 (B-1) monoclonal antibody an invaluable tool for studying nuclear transport mechanisms and Ran BP-17′s diverse roles in cellular and tissue-specific functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ran BP-17 Antibody (B-1) References:
- Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. | Kutay, U., et al. 2000. J Biol Chem. 275: 40163-8. PMID: 11024021
- Identification of a novel putative Ran-binding protein and its close homologue. | Koch, P., et al. 2000. Biochem Biophys Res Commun. 278: 241-9. PMID: 11071879
- Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. | Koolen, DA., et al. 2006. J Hum Genet. 51: 721-726. PMID: 16865294
- HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32). | Su, XY., et al. 2006. Blood. 108: 4198-201. PMID: 16926283
- RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids. | Bao, J., et al. 2011. Mol Cell Endocrinol. 333: 134-42. PMID: 21184802
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. | Mertens, J., et al. 2015. Cell Stem Cell. 17: 705-718. PMID: 26456686
- Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis. | Zhou, M., et al. 2021. J Cancer. 12: 4322-4331. PMID: 34093832
- The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC. | Mandic, R., et al. 2022. BMC Cancer. 22: 785. PMID: 35850701
- CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p. | Zhao, L., et al. 2023. Open Med (Wars). 18: 20230672. PMID: 36941992
- The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms. | Liu, M., et al. 2023. Oncologist. 28: e723-e736. PMID: 37086484
- NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors. | Wang, Y., et al. 2024. Cell Genom. 4: 100550. PMID: 38697125
- A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization. | Saltman, DL., et al. 1993. Genomics. 16: 726-32. PMID: 8325647
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ran BP-17 Antibody (B-1) | sc-518249 | 200 µg/ml | $316.00 | |||
Ran BP-17 Antibody (B-1): m-IgG1 BP-HRP Bundle | sc-551702 | 200 µg Ab; 20 µg BP | $354.00 | |||
Ran BP-17 Antibody (B-1) AC | sc-518249 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Ran BP-17 Antibody (B-1) HRP | sc-518249 HRP | 200 µg/ml | $316.00 | |||
Ran BP-17 Antibody (B-1) FITC | sc-518249 FITC | 200 µg/ml | $330.00 | |||
Ran BP-17 Antibody (B-1) PE | sc-518249 PE | 200 µg/ml | $343.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 488 | sc-518249 AF488 | 200 µg/ml | $357.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 546 | sc-518249 AF546 | 200 µg/ml | $357.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 594 | sc-518249 AF594 | 200 µg/ml | $357.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 647 | sc-518249 AF647 | 200 µg/ml | $357.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 680 | sc-518249 AF680 | 200 µg/ml | $357.00 | |||
Ran BP-17 Antibody (B-1) Alexa Fluor® 790 | sc-518249 AF790 | 200 µg/ml | $357.00 |