Ran BP-1 Antibody (35): sc-136054
- Ran BP-1 Antibody (35) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 28-163 of Ran BP-1 of human origin
- recommended for detection of Ran BP-1 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ran BP-1 Antibody (35). This work is in progress.
Ran BP-1 Antibody (35) is a mouse monoclonal IgG2a antibody that detects Ran BP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Ran BP-1 plays a crucial role in the regulation of the small Ras-related protein Ran, which is essential for various cellular processes, including the transport of proteins and RNA through the nuclear pore complex. By inhibiting the guanine nucleotide exchange factor RCC1, Ran BP-1 indirectly increases the levels of inactive Ran GDP, thereby influencing the balance between active and inactive forms of Ran. This regulation is vital for maintaining proper cellular function, particularly during cell division and the transport of genetic material. The interaction of Ran BP-1 with other proteins, such as Ran GAP1 and Ran BP2, further underscores its importance in the dynamics of nuclear transport and cellular signaling pathways. Anti-Ran BP-1 antibody (35) is an invaluable tool for researchers studying the intricate mechanisms of nuclear transport and the role of Ran in cellular processes.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ran BP-1 Antibody (35) References:
- Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1. | Geyer, M., et al. 1999. Biochemistry. 38: 11250-60. PMID: 10471274
- Random mutagenesis and functional analysis of the Ran-binding protein, RanBP1. | Petersen, C., et al. 2000. J Biol Chem. 275: 4081-91. PMID: 10660567
- Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. | Plafker, K. and Macara, IG. 2000. Mol Cell Biol. 20: 3510-21. PMID: 10779340
- Mice lacking Ran binding protein 1 are viable and show male infertility. | Nagai, M., et al. 2011. FEBS Lett. 585: 791-6. PMID: 21310149
- Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression. | Hwang, HI., et al. 2011. J Biol Chem. 286: 33012-20. PMID: 21813642
- High expression of Ran binding protein 1 predicts poor outcomes in hepatocellular carcinoma patients: a Cancer Genome Atlas database analysis. | Wei, Z., et al. 2021. J Gastrointest Oncol. 12: 2966-2984. PMID: 35070423
- RANBP1 (RAN Binding Protein 1): The Missing Genetic Piece in Cancer Pathophysiology and Other Complex Diseases. | Audia, S., et al. 2023. Cancers (Basel). 15: PMID: 36672435
- RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. | Hayashi, N., et al. 1995. Mol Gen Genet. 247: 661-9. PMID: 7616957
- RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import. | Chi, NC., et al. 1996. J Cell Biol. 135: 559-69. PMID: 8909533
- Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta. | Lounsbury, KM. and Macara, IG. 1997. J Biol Chem. 272: 551-5. PMID: 8995296
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ran BP-1 Antibody (35) | sc-136054 | 50 µg/0.5 ml | $316.00 |