Raf-1 Antibody (H-8): sc-376142
- Raf-1 Antibody (H-8) is a mouse monoclonal IgG3 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 621-655 near the C-terminus of Raf-1 of human origin
- recommended for detection of Raf-1 p74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- See Raf-1 (E-10): sc-7267 for Raf-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Raf-1 Antibody (H-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with Raf-1 Antibody (H-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Raf-1 Antibody (H-8) is a mouse monoclonal IgG3 antibody that recognizes Raf-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Raf-1 is a crucial serine/threonine protein kinase that plays a significant role in signal transduction pathways, particularly in the regulation of cell growth and differentiation. Located primarily in the cytoplasm, Raf-1 is activated by a variety of receptor tyrosine kinases and is essential for transmitting signals from these receptors to downstream effectors, such as the MAPK/ERK pathway. This pathway is vital for cellular responses to growth factors and mitogens, making Raf-1 a key player in processes such as cell proliferation and survival. Raf-1 activity is tightly regulated by its N-terminal domain, which prevents unregulated kinase activity under normal conditions. However, when activated, Raf-1 can lead to significant cellular changes, and dysregulation has been implicated in various cancers. Anti-Raf-1 antibody (H-8) provides a reliable tool for researchers studying these critical signaling pathways and their implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Raf-1 Antibody (H-8) | sc-376142 | 200 µg/ml | $322.00 | |||
Raf-1 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-522852 | 200 µg Ab, 40 µg BP | $361.00 | |||
Raf-1 (H-8) Neutralizing Peptide | sc-376142 P | 100 µg/0.5 ml | $69.00 |