Raf-1 Antibody (540): sc-52827
- Raf-1 Antibody (540) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 100 µg/ml
- raised against purified recombinant Raf-1 of human origin
- recommended for detection of Raf-1 of mouse, rat and human origin by WB and IP
- See Raf-1 (E-10): sc-7267 for Raf-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Raf-1 Antibody (540). This work is in progress.
Raf-1 Antibody (540) is a mouse monoclonal IgG1 antibody that detects Raf-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Raf-1 is a crucial serine/threonine protein kinase that plays a significant role in the regulation of cell signaling pathways, particularly in cell growth and differentiation. Located primarily in the cytoplasm, Raf-1 is activated by various receptor tyrosine kinases and is essential for transmitting signals from the cell membrane to downstream effectors, including the MAPK/ERK pathway. This pathway is vital for cellular responses to growth factors and mitogenic signals, making Raf-1 a key player in processes such as proliferation and survival. Raf-1 activity is tightly regulated by its N-terminal domain, which prevents unregulated kinase activity under normal conditions. However, aberrations in Raf-1 signaling can lead to oncogenic transformations, highlighting Raf-1′s importance in cancer biology. anti-Raf-1 antibody (540) is an invaluable tool for researchers studying these critical signaling pathways and their implications in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Raf-1 Antibody (540) | sc-52827 | 100 µg/ml | $316.00 |