Rad26L Antibody (E-10): sc-377506
- Rad26L Antibody (E-10) is a mouse monoclonal IgG1 κ Rad26L antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 335-367 within an internal region of Rad26L of human origin
- Rad26L Antibody (E-10) is recommended for detection of Rad26L isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- Anti-Rad26L Antibody (E-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Rad26L Antibody (E-10) for WB applications. This reagent is now offered in a bundle with Rad26L Antibody (E-10) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Rad26L Antibody (E-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rad26L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Rad26L antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rad26L, also known as ERCC6L2, HEBO, BMFS2, SR278, or C9orf102, plays a pivotal role in DNA repair processes, particularly in repairing DNA double-strand breaks through homologous recombination repair pathway. This function is crucial for maintaining genomic stability, as Rad26L helps prevent DNA damage accumulation that can lead to cancer and age-related diseases. Rad26L interacts with several key proteins involved in DNA repair, including RAD51, which is essential for homologous recombination, and BRCA1, a well-known tumor suppressor. These interactions underscore Rad26L′s importance in DNA repair mechanisms, highlighting potential therapeutic applications in diseases associated with genomic instability. Research into Rad26L continues providing valuable insights into cellular defense against DNA damage, making Rad26L a significant focus for understanding molecular basis of genomic maintenance and human health implications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rad26L Antibody (E-10) References:
- DNA sequence and analysis of human chromosome 9. | Humphray, SJ., et al. 2004. Nature. 429: 369-74. PMID: 15164053
- BCR-ABL activates STAT3 via JAK and MEK pathways in human cells. | Coppo, P., et al. 2006. Br J Haematol. 134: 171-9. PMID: 16846476
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Gene expression fingerprinting for human hereditary hemorrhagic telangiectasia. | Fernandez-L, A., et al. 2007. Hum Mol Genet. 16: 1515-33. PMID: 17420163
- Phenotypic and cytogenetic spectrum of 9p trisomy. | Temtamy, SA., et al. 2007. Genet Couns. 18: 29-48. PMID: 17515299
- Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. | Gardiner, J., et al. 2007. Traffic. 8: 1145-9. PMID: 17605759
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect. | Hims, MM., et al. 2007. Genomics. 90: 389-96. PMID: 17644305
- Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia. | Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad26L Antibody (E-10) | sc-377506 | 200 µg/ml | $316.00 | |||
Rad26L Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-523350 | 200 µg Ab, 40 µg BP | $354.00 | |||
Rad26L Antibody (E-10) AC | sc-377506 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Rad26L Antibody (E-10) HRP | sc-377506 HRP | 200 µg/ml | $316.00 | |||
Rad26L Antibody (E-10) FITC | sc-377506 FITC | 200 µg/ml | $330.00 | |||
Rad26L Antibody (E-10) PE | sc-377506 PE | 200 µg/ml | $343.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 488 | sc-377506 AF488 | 200 µg/ml | $357.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 546 | sc-377506 AF546 | 200 µg/ml | $357.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 594 | sc-377506 AF594 | 200 µg/ml | $357.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 647 | sc-377506 AF647 | 200 µg/ml | $357.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 680 | sc-377506 AF680 | 200 µg/ml | $357.00 | |||
Rad26L Antibody (E-10) Alexa Fluor® 790 | sc-377506 AF790 | 200 µg/ml | $357.00 | |||
Rad26L (E-10) Neutralizing Peptide | sc-377506 P | 100 µg/0.5 ml | $68.00 |