Rad23B Antibody (16): sc-136052
- Rad23B Antibody (16) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 73-193 of Rad23B of human origin
- recommended for detection of RAd23B of human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rad23B Antibody (16). This work is in progress.
Rad23B Antibody (16) is a mouse monoclonal IgG1 antibody that detects RAD23B in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). RAD23B is a crucial player in the nucleotide excision repair (NER) pathway, which is essential for maintaining genomic stability by repairing UV-induced DNA damage. RAD23B is predominantly located in the nucleus, where RAD23B interacts with the 26S proteasome, facilitating the degradation of damaged proteins and thus playing a vital role in cellular homeostasis. RAD23B helps regulate the stability of the xeroderma pigmentosum C protein (XPC), which is necessary for recognizing and initiating the repair of DNA lesions. Loss of RAD23B significantly reduces the levels of XPC, underscoring RAD23B′s importance in the DNA damage response. RAD23B contains an evolutionarily conserved ubiquitin-like domain that is critical for function, highlighting RAD23B′s role in linking DNA repair processes with proteasomal degradation. With high conservation across species, RAD23B serves as a key target for studying DNA repair mechanisms and their implications in various diseases, including cancer.
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Rad23B Antibody (16) References:
- Expression of a novel RAD23B mRNA splice variant in the human testis. | Huang, X., et al. 2004. J Androl. 25: 363-8. PMID: 15064313
- Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells. | Renaud, E., et al. 2011. DNA Repair (Amst). 10: 835-47. PMID: 21676658
- Erythropoietic defect associated with reduced cell proliferation in mice lacking the 26S proteasome shuttling factor Rad23b. | Bergink, S., et al. 2013. Mol Cell Biol. 33: 3879-92. PMID: 23897431
- Poly(ADP-ribose) Polymerase 1 Modulates Interaction of the Nucleotide Excision Repair Factor XPC-RAD23B with DNA via Poly(ADP-ribosyl)ation. | Maltseva, EA., et al. 2015. J Biol Chem. 290: 21811-20. PMID: 26170451
- Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs. | You, X., et al. 2017. Cell Signal. 36: 108-116. PMID: 28473198
- Circular RNA circ-RAD23B promotes cell growth and invasion by miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways in non-small cell lung cancer. | Han, W., et al. 2019. Biochem Biophys Res Commun. 510: 462-466. PMID: 30722989
- Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B. | Cheon, NY., et al. 2019. Nucleic Acids Res. 47: 8337-8347. PMID: 31372632
- Irisin attenuates lipopolysaccharide-induced acute lung injury by downregulating inflammatory cytokine expression through miR-199a-mediated Rad23b overexpression. | Ma, LY., et al. 2021. Exp Cell Res. 404: 112593. PMID: 33961841
- Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B. | Wang, J., et al. 2021. Int J Biol Sci. 17: 3331-3342. PMID: 34512150
- RAD23B mediated proteasomal degradation occurs through p38 MAPK/ATF-2/RAD23B axis under nutrient-deprived conditions in breast cancer. | Sriaishwarya, S. and Lakshmi, BS. 2024. Cell Biol Int.. PMID: 38561940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rad23B Antibody (16) | sc-136052 | 50 µg/0.5 ml | $316.00 |