RACK7 Antibody (RF-9): sc-100824

RACK7 Antibody (RF-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects RACK7 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-RACK7 antibody (RF-9) is available as a non-conjugated format. RACK7, also known as ZMYND8 (zinc finger MYND domain-containing protein 8), plays a crucial role in cellular signaling and gene regulation, particularly in response to DNA damage. RACK7 is primarily located in the nucleus, where ZMYND8 is involved in transcription regulation and cellular stress response. Nuclear localization of RACK7 enables interaction with various transcription factors and chromatin remodeling complexes, influencing gene expression patterns vital for maintaining cellular homeostasis and responding to environmental changes. RACK7 contains multiple functional domains, including a bromodomain and zinc finger motifs, which facilitate interactions with other proteins and contribute to regulatory functions. In response to DNA damage, RACK7 undergoes phosphorylation by ATM or ATR, highlighting ZMYND8′s role in cellular response to genotoxic stress. With diverse interactions and regulatory capabilities, RACK7 remains essential for proper cellular function and has implications in various biological processes, including cell growth, differentiation, and survival.

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RACK7 Antibody (RF-9) References:

1. Identification and characterization of PRKCBP1, a candidate RACK-like protein.  |  Fossey, SC., et al. 2000. Mamm Genome. 11: 919-25. PMID: 11003709
2. Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1).  |  Zhang, Y., et al. 2001. Food Chem Toxicol. 39: 45-53. PMID: 11259850
3. Mutation profiling of mismatch repair-deficient colorectal cncers using an in silico genome scan to identify coding microsatellites.  |  Park, J., et al. 2002. Cancer Res. 62: 1284-8. PMID: 11888892
4. [BS69 and RACK7, a potential novel class of tumor suppressor genes].  |  Ansieau, S. and Sergeant, A. 2003. Pathol Biol (Paris). 51: 397-9. PMID: 12948759
5. Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics.  |  Westendorf, JJ. and Koka, S. 2004. J Cell Biochem. 92: 29-41. PMID: 15095401
6. Analysis of BCL6-interacting proteins by tandem mass spectrometry.  |  Miles, RR., et al. 2005. Mol Cell Proteomics. 4: 1898-909. PMID: 16147992
7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.  |  Lim, J., et al. 2006. Cell. 125: 801-14. PMID: 16713569
8. A snapshot of microarray-generated gene expression signatures associated with ovarian carcinoma.  |  Györffy, B., et al. 2008. Int J Gynecol Cancer. 18: 1215-33. PMID: 18217975
9. Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex.  |  Shen, H., et al. 2016. Cell. 165: 331-42. PMID: 27058665
10. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.  |  Li, N., et al. 2016. Mol Cell. 63: 470-84. PMID: 27477906
11. RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.  |  Jiao, F., et al. 2020. Sci Adv. 6: eaba2113. PMID: 32832624
12. i-Motif formation and spontaneous deletions in human cells.  |  Martella, M., et al. 2022. Nucleic Acids Res. 50: 3445-3455. PMID: 35253884

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RACK7 Antibody (RF-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-RACK7 Antibody (RF-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RACK7 Antibody (RF-9) Specifications

Alternate Product Name: RACK7

Product Clone Name: RF-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 601-699

Epitope Target: RACK7

Epitope Species: human

Product Reactivity/Detection: RACK7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for RACK7 Antibody (RF-9): N/A