Rabies Virus Antibody (5B12): sc-52180

Rabies Virus Antibody (5B12) is a mouse monoclonal IgG2a antibody that detects Rabies Virus by enzyme-linked immunosorbent assay (ELISA) applications. Rabies Virus is a neurotropic lyssavirus belonging to the Rhabdoviridae family, characterized by its single-stranded, negative-sense RNA genome that encodes five essential proteins, including a glycoprotein and a nucleoprotein. The glycoprotein plays a crucial role in viral infection of host cells by facilitating attachment and entry into the host′s central nervous system, leading to severe neurological consequences. The mature virus exhibits a distinctive bullet shape, with a protein coat enveloped in a lipid membrane, and is adorned with glycoprotein projections that are vital for infectivity. The structure of Rabies Virus, averaging approximately 780 nm in length, is designed to evade host immune response, making Rabies Virus a highly successful pathogen with a wide range of susceptible hosts. Each year, Rabies Virus causes approximately 50,000 human deaths, underscoring the importance of understanding viral biology and developing effective diagnostic tools, such as anti-Rabies Virus antibody (5B12), to combat this deadly virus.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Rabies Virus Antibody (5B12) References:

1. Rabies virus as a transneuronal tracer of neuronal connections.  |  Ugolini, G. 2011. Adv Virus Res. 79: 165-202. PMID: 21601048
2. Rabies virus infection and microRNAs.  |  Israsena, N., et al. 2011. Adv Virus Res. 79: 329-44. PMID: 21601053
3. Inactivation of rabies virus by hydrogen peroxide.  |  Abd-Elghaffar, AA., et al. 2016. Vaccine. 34: 798-802. PMID: 26731189
4. Subversion of the Immune Response by Rabies Virus.  |  Scott, TP. and Nel, LH. 2016. Viruses. 8: PMID: 27548204
5. The phylodynamics of the rabies virus in the Russian Federation.  |  Deviatkin, AA., et al. 2017. PLoS One. 12: e0171855. PMID: 28225771
6. Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication.  |  Luo, J., et al. 2021. Virol Sin. 36: 721-729. PMID: 33661488
7. Review of Detection and Quantification of Rabies Virus Antibodies.  |  Su, K., et al. 2021. Viral Immunol. 34: 522-530. PMID: 34550784
8. Trim25 restricts rabies virus replication by destabilizing phosphoprotein.  |  Yuan, Y., et al. 2022. Cell Insight. 1: 100057. PMID: 37193556
9. Genomic Surveillance of Rabies Virus in Georgian Canines.  |  Huaman, C., et al. 2023. Viruses. 15: PMID: 37766204
10. Rabies Virus Infection Causes Pyroptosis of Neuronal Cells.  |  Yu, D., et al. 2024. Int J Mol Sci. 25: PMID: 38891803

The preferred Rabies Virus antibody is Rabies Virus Antibody (Rab-50): sc-57994.