Rabies Virus Antibody (Rab-50): sc-57994

Rabies Virus Antibody (Rab-50) is a mouse monoclonal IgG2b antibody that detects the Rabies Virus protein of Rabies virus origin by western blotting (WB) and immunofluorescence (IF). Anti-Rabies Virus antibody (Rab-50) is available as the non-conjugated form. The Rabies virus, a member of the Rhabdoviridae family, is a single-stranded, neurotropic, negative-sense RNA virus that encodes five proteins, including a glycoprotein and a nucleoprotein, which are crucial for infectivity and pathogenicity. The glycoprotein plays a vital role in virus attachment and host cell entry, facilitating spread within the central nervous system. This interaction enables virus evasion of host immune response and establishment of productive infection. The mature virus exhibits a characteristic bullet shape, with a protein coat enveloped in a lipid membrane, adorned with glycoprotein projections critical for receptor binding. Rabies Virus monoclonal antibody (Rab-50) serves as an invaluable tool for researchers studying rabies virus infection mechanisms and nervous system impact, as well as for developing therapeutic strategies against this deadly virus, which causes approximately 50,000 human deaths annually.

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Rabies Virus Antibody (Rab-50) References:

1. DNA vaccination of mice against rabies virus: effects of the route of vaccination and the adjuvant monophosphoryl lipid A (MPL).  |  Lodmell, DL., et al. 2000. Vaccine. 18: 1059-66. PMID: 10590326
2. Comparative immunogenicity and efficacy studies with oral rabies virus vaccine SAD P5/88 in raccoon dogs and red foxes.  |  Schuster, P., et al. 2001. Acta Vet Hung. 49: 285-90. PMID: 11702339
3. Canine vaccine recipients recognize an immunodominant region of the rabies virus glycoprotein.  |  Johnson, N., et al. 2002. J Gen Virol. 83: 2663-2669. PMID: 12388801
4. Preservation of rabies virus RNA from brain tissue using glycerine.  |  Aguilar-Setién, A., et al. 2003. Trans R Soc Trop Med Hyg. 97: 547-9. PMID: 15307422
5. Wild rabies virus detection by plaque assay from naturally infected brains in different species.  |  Cardoso, T. and Pilz, D. 2004. Vet Microbiol. 103: 161-7. PMID: 15504587
6. Characterization of P gene-deficient rabies virus: propagation, pathogenicity and antigenicity.  |  Morimoto, K., et al. 2005. Virus Res. 111: 61-7. PMID: 15896403
7. Crystal structure of the rabies virus nucleoprotein-RNA complex.  |  Albertini, AA., et al. 2006. Science. 313: 360-3. PMID: 16778023
8. Rabies virus infection of primary neuronal cultures and adult mice: failure to demonstrate evidence of excitotoxicity.  |  Weli, SC., et al. 2006. J Virol. 80: 10270-3. PMID: 17005706
9. Pseudotyping of G-Gene-Deficient Rabies Virus.  |  Hagendorf, N. and Conzelmann, KK. 2015. Cold Spring Harb Protoc. 2015: pdb.prot089417. PMID: 26631128
10. Genomic sequencing, evolution and molecular epidemiology of rabies virus.  |  Brunker, K., et al. 2018. Rev Sci Tech. 37: 401-408. PMID: 30747139
11. Rabies virus diversification in aerial and terrestrial mammals.  |  Oliveira, RN., et al. 2020. Genet Mol Biol. 43: e20190370. PMID: 32745160
12. Budding of rabies virus particles in the absence of the spike glycoprotein.  |  Mebatsion, T., et al. 1996. Cell. 84: 941-51. PMID: 8601317

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rabies Virus Antibody (Rab-50) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rabies Virus Antibody (Rab-50) Specifications

Alternate Product Name: Rabies Virus

Product Clone Name: Rab-50

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Rabies Virus

Epitope Species: Rabies virus

Product Reactivity/Detection: a viral glycoprotein of strains SAD-Vnukovo and Pitman-Moore

Species Reactivity/Detection: Rabies virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Rabies Virus Antibody (Rab-50): N/A