Rabies Virus Antibody (4G4): sc-52179

Rabies Virus Antibody (4G4) is a mouse monoclonal IgG2a antibody that specifically detects Rabies Virus by enzyme-linked immunosorbent assay (ELISA). Anti-Rabies Virus antibody (4G4) plays a crucial role in studying the rabies virus, a neurotropic lyssavirus known for devastating effects on the central nervous system, leading to severe neurological symptoms and often death. The rabies virus genome encodes five proteins, including a glycoprotein essential for viral attachment and host cell entry. This glycoprotein facilitates viral entry and helps evade host immune response, making it a key target for vaccine development and therapeutic interventions. The rabies virus structure, characterized by a bullet shape and lipid envelope with glycoprotein projections, is vital for infectivity and pathogenicity. Understanding glycoprotein interactions with host cell receptors provides insights into viral entry mechanisms and treatment development. Rabies Virus (4G4) monoclonal antibody serves as an invaluable tool for researchers investigating rabies virus biology and public health impact, particularly given approximately 50,000 human deaths attributed to rabies annually.

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Rabies Virus Antibody (4G4) References:

1. Recombination in the rabies virus and other lyssaviruses.  |  Deviatkin, AA. and Lukashev, AN. 2018. Infect Genet Evol. 60: 97-102. PMID: 29477551
2. Rabies virus transmission via solid organs or tissue allotransplantation.  |  Lu, XX., et al. 2018. Infect Dis Poverty. 7: 82. PMID: 30107857
3. Rabies virus vectors and reservoir species.  |  Gilbert A, T. 2018. Rev Sci Tech. 37: 371-384. PMID: 30747141
4. Rabies virus-mediated connectivity tracing from single neurons.  |  Schwarz, MK. and Remy, S. 2019. J Neurosci Methods. 325: 108365. PMID: 31330160
5. Regulation of innate immune responses by rabies virus.  |  Zhang, H., et al. 2022. Animal Model Exp Med. 5: 418-429. PMID: 36138548
6. Morphogenesis of Bullet-Shaped Rabies Virus Particles Regulated by TSG101.  |  Itakura, Y., et al. 2023. J Virol. 97: e0043823. PMID: 37042780
7. TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination.  |  Zhang, B., et al. 2023. Int J Mol Sci. 24: PMID: 37446070
8. Research progress on neutralizing epitopes and antibodies for the Rabies virus.  |  Shi, C., et al. 2022. Infect Med (Beijing). 1: 262-271. PMID: 38075404
9. Autophagy and Apoptosis in Rabies Virus Replication.  |  Li, S., et al. 2024. Cells. 13: PMID: 38247875
10. TRIM44 Promotes Rabies Virus Replication by Autophagy-Dependent Mechanism.  |  He, H., et al. 2024. Int J Mol Sci. 25: PMID: 38731834

The preferred Rabies Virus antibody is Rabies Virus Antibody (Rab-50): sc-57994.