Rab 5A Antibody (C-3): sc-515401

Rab 5A Antibody (C-3) is a mouse monoclonal IgM kappa antibody that detects Rab 5A from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 5A antibody (C-3) is available in a non-conjugated form, providing flexibility for various experimental needs. Rab 5A is a member of the Ras-related superfamily of guanine nucleotide-binding proteins, which play crucial roles in intracellular transport processes. Specifically, Rab 5A is primarily located on early endosomes, where Rab 5A is essential for the regulation of endocytosis and the fusion of vesicles with these organelles. This localization is vital because Rab 5A ensures the proper sorting and delivery of internalized materials, including nutrients and signaling molecules, to their intended destinations within the cell. Rab 5A′s function in endosomal trafficking is further underscored by interactions with various effector proteins that facilitate vesicle movement and fusion, highlighting Rab 5A′s importance in maintaining cellular homeostasis and responding to extracellular signals. With an ability to provide insights into the dynamics of membrane transport, Rab 5A (C-3) monoclonal antibody is an invaluable tool for researchers studying cellular processes related to endocytosis and vesicular trafficking.

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Rab 5A Antibody (C-3) References:

1. Characterization of a small GTP-binding protein of the rab 5 family in Mesembryanthemum crystallinum with increased level of expression during early salt stress.  |  Bolte, S., et al. 2000. Plant Mol Biol. 42: 923-36. PMID: 10890538
2. Rab 5 is required for the cellular entry of dengue and West Nile viruses.  |  Krishnan, MN., et al. 2007. J Virol. 81: 4881-5. PMID: 17301152
3. RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin.  |  Los, FC., et al. 2011. Cell Host Microbe. 9: 147-57. PMID: 21320697
4. CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.  |  Sun, L., et al. 2012. PLoS Genet. 8: e1002785. PMID: 22807685
5. Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.  |  Liu, O. and Grant, BD. 2015. PLoS Genet. 11: e1005514. PMID: 26393361
6. RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.  |  Smurova, K. and Podbilewicz, B. 2016. Cell Rep. 14: 1517-1527. PMID: 26854231
7. LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling.  |  Liu, H., et al. 2018. J Cell Biol. 217: 299-314. PMID: 29079669
8. Disruption of RAB-5 Increases EFF-1 Fusogen Availability at the Cell Surface and Promotes the Regenerative Axonal Fusion Capacity of the Neuron.  |  Linton, C., et al. 2019. J Neurosci. 39: 2823-2836. PMID: 30737314
9. Analysis of Gtpases Rab 5 and Rab 7 expression from macrophages infected with biofilm-producing and non biofilm-producing strains of Corynebacterium pseudotuberculosis.  |  da Conceição Aquino de Sá, M., et al. 2022. Braz J Microbiol. 53: 447-453. PMID: 35023082
10. Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen granule membranes.  |  Wagner, AC., et al. 1994. Biochem Biophys Res Commun. 200: 542-8. PMID: 8166729

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 5A Antibody (C-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 5A Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 5A Antibody (C-3) Specifications

Alternate Product Name: RAB5A

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 185-202

Epitope Target: Rab 5A

Epitope Species: human

Product Reactivity/Detection: Rab 5A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Rab 5A Antibody (C-3): P: Blocking Peptide

The preferred Rab 5 antibody is Rab 5 Antibody (D-11): sc-46692.