Date published: 2025-10-19

1-800-457-3801

SCBT Portrait Logo
Seach Input

Rab 4B Antibody (H-3): sc-376386

5.0(1)
Write a reviewAsk a question

Datasheets
  • Rab 4B Antibody (H-3) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 197-213 at the C-terminus of Rab 4B of human origin
  • recommended for detection of Rab 4B of mouse, rat and human origin by WB, IP, IF and ELISA
  • m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rab 4B Antibody (H-3) for WB applications. These reagents are now offered in bundles with Rab 4B Antibody (H-3) (see ordering information below).

QUICK LINKS

SEE ALSO...

Rab 4B Antibody (H-3) is a mouse monoclonal IgG1 antibody that detects Rab 4B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 4B plays a crucial role in the regulation of endosomal trafficking, particularly in the recycling of proteins from endosomes back to the plasma membrane, which is vital for maintaining cellular homeostasis and membrane composition. This recycling process is essential for various cellular functions, including nutrient uptake, receptor signaling, and the removal of damaged proteins. The proper functioning of Rab 4B is linked to its ability to interact with specific effector proteins that facilitate the movement of vesicles within the cell, ensuring that proteins are delivered to their correct destinations. Disruptions in Rab 4B function can lead to significant cellular dysfunction and are implicated in various diseases, making Rab 4B an important target for research in cell biology and therapeutic development. Anti-Rab 4B antibody (H-3) provides a reliable tool for studying the dynamics of endosomal trafficking and the role of Rab proteins in cellular processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Rab 4B Antibody (H-3) References:

  1. Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes.  |  Krawczyk, M., et al. 2007. Nucleic Acids Res. 35: 595-605. PMID: 17175541
  2. Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte.  |  Kaddai, V., et al. 2009. PLoS One. 4: e5257. PMID: 19590752
  3. Small GTPase Rab4b participates in the gene transcription of 20-hydroxyecdysone and insulin pathways to regulate glycogen level and metamorphosis.  |  Hou, L., et al. 2012. Dev Biol. 371: 13-22. PMID: 22824427
  4. Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1.  |  Perrin, L., et al. 2013. J Cell Sci. 126: 4950-62. PMID: 24006255
  5. Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.  |  Thean, LF., et al. 2017. PLoS One. 12: e0173772. PMID: 28306719
  6. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.  |  Gilleron, J., et al. 2018. Cell Rep. 25: 3329-3341.e5. PMID: 30566860
  7. Preliminary exploration of the potential biological functions and prognosis values of RAB4B in pan-cancer combing with experimental validation in BLCA.  |  Li, K., et al. 2024. Transl Cancer Res. 13: 613-633. PMID: 38482438
  8. Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.  |  Gilleron, J., et al. 2024. Cell Mol Biol Lett. 29: 54. PMID: 38627612
  9. Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells.  |  Zhang, Y., et al. 2024. Toxins (Basel). 16: PMID: 39330865
  10. RAB4B and Japanese encephalitis virus E protein interaction is essential for viral entry in early endosomes.  |  Miao, C., et al. 2025. Int J Biol Macromol. 306: 141452. PMID: 40020812

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rab 4B Antibody (H-3)

sc-376386
200 µg/ml
$316.00

Rab 4B Antibody (H-3): m-IgG Fc BP-HRP Bundle

sc-540559
200 µg Ab; 10 µg BP
$354.00

Rab 4B Antibody (H-3): m-IgG1 BP-HRP Bundle

sc-542206
200 µg Ab; 20 µg BP
$354.00

Rab 4B (H-3) Neutralizing Peptide

sc-376386 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-376386 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
  • y_2025, m_10, d_14, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_376386, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 102ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Worked well in human Rab 4B transfected 293TWorked well in human Rab 4B transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-01-22
  • y_2025, m_10, d_14, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_376386, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
Rab 4B Antibody (H-3) is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_14, h_6
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_376386, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 104ms
  • REVIEWS, PRODUCT