Rab 4A Antibody (4E11): sc-517263

Rab 4A Antibody (4E11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 4A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 4A antibody (4E11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 4A protein plays a crucial role in intracellular transport, particularly in vesicle movement between the endoplasmic reticulum and Golgi apparatus, which is essential for proper protein secretion. Rab 4A regulates endocytosis and exocytosis, processes vital for maintaining cellular homeostasis and communication. Rab 4A facilitates transport of newly synthesized proteins to correct destinations within cells, influencing various cellular functions and signaling pathways. Rab proteins, including Rab 4A, interact with specific effector proteins that mediate docking and fusion of transport vesicles with target membranes, highlighting their importance in cellular logistics.

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Rab 4A Antibody (4E11) References:

1. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
2. Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.  |  Fukuda, M. 2005. J Biochem. 137: 9-16. PMID: 15713878
3. Cloning of a Rab3 isotype predominantly expressed in adipocytes.  |  Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
4. Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.  |  Sato, M., et al. 2008. EMBO J. 27: 1183-96. PMID: 18354496
5. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
6. Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel.  |  Kogel, A., et al. 2022. Cell Calcium. 106: 102634. PMID: 35917684
7. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.  |  Chen, YT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6508-12. PMID: 7688123
8. Coatomers and SNAREs in promoting membrane traffic.  |  Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
9. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
10. The role of GTP-binding proteins in transport along the exocytic pathway.  |  Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
11. Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.  |  Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
12. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.  |  Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 4A Antibody (4E11) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 4A Antibody (4E11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 4A Antibody (4E11) Specifications

Alternate Product Name: Rab 4A

Product Clone Name: 4E11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 22-218

Epitope Target: Rab 4A

Epitope Species: human

Product Reactivity/Detection: Rab 4A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Rab 4A Antibody (4E11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Rab 4/14 antibody is Rab 4/14 Antibody (F-10): sc-376243.