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Rab 40C Antibody (H-8): sc-514826

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Datasheets
  • Rab 40C Antibody (H-8) is a mouse monoclonal IgG1 κ Rab 40C antibody, cited in 3 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 248-267 near the C-terminus of Rab 40C of human origin
  • Rab 40C Antibody (H-8) is recommended for detection of Rab 40C of mouse, rat and human origin by WB, IP, IF and ELISA
  • Anti-Rab 40C Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Rab 40C Antibody (H-8) for WB applications. These reagents are now offered in bundles with Rab 40C Antibody (H-8) (see ordering information below).

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Rab 40C Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 40C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 40C (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 40C protein, consisting of 281 amino acids, is a member of the small GTPase superfamily and the Rab family, playing a crucial role in intracellular trafficking and protein modification. Notably, Rab 40C contains a SOCS box domain that facilitates interaction with the Elongin BC complex, which is essential for the function of various E3 ubiquitin ligase complexes. This interaction positions Rab 40C as a probable substrate-recognition component of a SCF-like Elongin-Cullin-SOCS-box protein E3 ubiquitin ligase complex, thereby mediating ubiquitination and subsequent proteasomal degradation of target proteins. Rab 40C′s ability to regulate protein turnover is vital for maintaining cellular homeostasis and responding to stress signals. Additionally, Rab 40C interacts with key proteins such as CUL-5, Rbx2, Elongin C, and Elongin B, underscoring importance in cellular signaling pathways. Rab 40C gene is conserved across various species, including chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito, and is located on human chromosome 16p13.3, highlighting evolutionary significance and potential as a target for therapeutic interventions.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

Rab 40C Antibody (H-8) References:

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.  |  Daniels, RJ., et al. 2001. Hum Mol Genet. 10: 339-52. PMID: 11157797
  2. Evolution of the Rab family of small GTP-binding proteins.  |  Pereira-Leal, JB. and Seabra, MC. 2001. J Mol Biol. 313: 889-901. PMID: 11697911
  3. The SOCS box: a tale of destruction and degradation.  |  Kile, BT., et al. 2002. Trends Biochem Sci. 27: 235-41. PMID: 12076535
  4. Vesicle transport in oligodendrocytes: probable role of Rab40c protein.  |  Rodriguez-Gabin, AG., et al. 2004. J Neurosci Res. 76: 758-70. PMID: 15160388
  5. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.  |  Kamura, T., et al. 2004. Genes Dev. 18: 3055-65. PMID: 15601820
  6. The sequence and analysis of duplication-rich human chromosome 16.  |  Martin, J., et al. 2004. Nature. 432: 988-94. PMID: 15616553
  7. Rab GTPases and their roles in brain neurons and glia.  |  Ng, EL. and Tang, BL. 2008. Brain Res Rev. 58: 236-46. PMID: 18485483
  8. Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets.  |  Tan, R., et al. 2013. PLoS One. 8: e63213. PMID: 23638186
  9. Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP.  |  Fukuda, M. 2016. Traffic. 17: 709-19. PMID: 27103185
  10. Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile Inflammation.  |  Hegde, B., et al. 2018. J Immunol. 200: 3556-3567. PMID: 29610142
  11. Small GTPase Rab40C is upregulated by 20-hydroxyecdysone and insulin pathways to regulate ovarian development and fecundity.  |  Zheng, W., et al. 2022. Insect Sci. 29: 1583-1600. PMID: 35349758
  12. An Integrative Analysis Identifying RAB40C as an Oncogenic Immune Protein and Prognostic Marker of Lung Squamous Cell Carcinoma.  |  Wu, H., et al. 2022. Pharmgenomics Pers Med. 15: 525-537. PMID: 35645578

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rab 40C Antibody (H-8)

sc-514826
200 µg/ml
$316.00

Rab 40C Antibody (H-8): m-IgG Fc BP-HRP Bundle

sc-531228
200 µg Ab; 10 µg BP
$354.00

Rab 40C Antibody (H-8): m-IgGκ BP-HRP Bundle

sc-524855
200 µg Ab, 40 µg BP
$354.00

Rab 40C Antibody (H-8) AC

sc-514826 AC
500 µg/ml, 25% agarose
$416.00

Rab 40C Antibody (H-8) HRP

sc-514826 HRP
200 µg/ml
$316.00

Rab 40C Antibody (H-8) FITC

sc-514826 FITC
200 µg/ml
$330.00

Rab 40C Antibody (H-8) PE

sc-514826 PE
200 µg/ml
$343.00

Rab 40C Antibody (H-8) Alexa Fluor® 488

sc-514826 AF488
200 µg/ml
$357.00

Rab 40C Antibody (H-8) Alexa Fluor® 546

sc-514826 AF546
200 µg/ml
$357.00

Rab 40C Antibody (H-8) Alexa Fluor® 594

sc-514826 AF594
200 µg/ml
$357.00

Rab 40C Antibody (H-8) Alexa Fluor® 647

sc-514826 AF647
200 µg/ml
$357.00

Rab 40C Antibody (H-8) Alexa Fluor® 680

sc-514826 AF680
200 µg/ml
$357.00

Rab 40C Antibody (H-8) Alexa Fluor® 790

sc-514826 AF790
200 µg/ml
$357.00

Rab 40C (H-8) Neutralizing Peptide

sc-514826 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-514826 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Great for Western Blot detection of Rab 40CThis antibody detects a strong band at the expected molecular weight in human cell lines Jurkat and HeLa and in mouse brain tissue extract. -SCBT QC
Date published: 2023-09-14
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Rab 40C Antibody (H-8) is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_14, h_6
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