Rab 40C Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 40C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 40C (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 40C protein, consisting of 281 amino acids, is a member of the small GTPase superfamily and the Rab family, playing a crucial role in intracellular trafficking and protein modification. Notably, Rab 40C contains a SOCS box domain that facilitates interaction with the Elongin BC complex, which is essential for the function of various E3 ubiquitin ligase complexes. This interaction positions Rab 40C as a probable substrate-recognition component of a SCF-like Elongin-Cullin-SOCS-box protein E3 ubiquitin ligase complex, thereby mediating ubiquitination and subsequent proteasomal degradation of target proteins. Rab 40C′s ability to regulate protein turnover is vital for maintaining cellular homeostasis and responding to stress signals. Additionally, Rab 40C interacts with key proteins such as CUL-5, Rbx2, Elongin C, and Elongin B, underscoring importance in cellular signaling pathways. Rab 40C gene is conserved across various species, including chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito, and is located on human chromosome 16p13.3, highlighting evolutionary significance and potential as a target for therapeutic interventions.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 40C Antibody (H-8) | sc-514826 | 200 µg/ml | $316.00 | |||
Rab 40C Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-531228 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rab 40C Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-524855 | 200 µg Ab, 40 µg BP | $354.00 | |||
Rab 40C Antibody (H-8) AC | sc-514826 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Rab 40C Antibody (H-8) HRP | sc-514826 HRP | 200 µg/ml | $316.00 | |||
Rab 40C Antibody (H-8) FITC | sc-514826 FITC | 200 µg/ml | $330.00 | |||
Rab 40C Antibody (H-8) PE | sc-514826 PE | 200 µg/ml | $343.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 488 | sc-514826 AF488 | 200 µg/ml | $357.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 546 | sc-514826 AF546 | 200 µg/ml | $357.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 594 | sc-514826 AF594 | 200 µg/ml | $357.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 647 | sc-514826 AF647 | 200 µg/ml | $357.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 680 | sc-514826 AF680 | 200 µg/ml | $357.00 | |||
Rab 40C Antibody (H-8) Alexa Fluor® 790 | sc-514826 AF790 | 200 µg/ml | $357.00 | |||
Rab 40C (H-8) Neutralizing Peptide | sc-514826 P | 100 µg/0.5 ml | $68.00 |