Rab 33A Antibody (EA-65): sc-130433
- Rab 33A Antibody (EA-65) is a mouse monoclonal IgG2a κ Rab 33A antibody provided at 100 µg/ml
- raised against recombinant Rab 33A of human origin
- recommended for detection of Rab 33A of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 33A Antibody (EA-65). This work is in progress.
Rab 33A Antibody (EA-65) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Rab 33A protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Rab 33A antibody (EA-65) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Rab 33A is a member of the Ras-related superfamily of guanine nucleotide-binding proteins, which play crucial roles in cellular processes such as endocytosis and biosynthetic protein transport. Specifically, Rab 33A is predominantly expressed in CD8+ T cells and has been implicated in the immune response to tuberculosis, highlighting its significance in infectious disease mechanisms. Rab 33A′s location within the cell is particularly important, as Rab 33A is involved in the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi complex and secretory vesicles, a process that is essential for maintaining cellular function and homeostasis. Additionally, Rab 33A shares conserved effector domains with Rab 33B, suggesting potential interactions with similar effector and regulatory proteins, which may further elucidate Rab 33A′s role in intracellular transport and immune responses. Rab 33A monoclonal antibody (EA-65) enables researchers to gain valuable insights into the dynamics of protein transport and the functional implications of Rab 33A in health and disease.
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Rab 33A Antibody (EA-65) References:
- Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER. | Valsdottir, R., et al. 2001. FEBS Lett. 508: 201-9. PMID: 11718716
- Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. | Junutula, JR., et al. 2004. Mol Biol Cell. 15: 2218-29. PMID: 15004230
- Cisternal rab proteins regulate Golgi apparatus redistribution in response to hypotonic stress. | Jiang, S. and Storrie, B. 2005. Mol Biol Cell. 16: 2586-96. PMID: 15758030
- Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. | Jacobsen, M., et al. 2005. J Infect Dis. 192: 1211-8. PMID: 16136464
- Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21. | Dastani, Z., et al. 2006. Arterioscler Thromb Vasc Biol. 26: 392-7. PMID: 16322534
- Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. | Carney, DS., et al. 2006. Trends Cell Biol. 16: 27-35. PMID: 16330212
- Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. | Itoh, T., et al. 2006. Genes Cells. 11: 1023-37. PMID: 16923123
- Rab14 is part of the early endosomal clathrin-coated TGN microdomain. | Proikas-Cezanne, T., et al. 2006. FEBS Lett. 580: 5241-6. PMID: 16962593
- A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. | Zheng, JY., et al. 1998. J Cell Sci. 111 (Pt 8): 1061-9. PMID: 9512502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 33A Antibody (EA-65) | sc-130433 | 100 µg/ml | $333.00 |