Date published: 2025-10-19

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Rab 23 Antibody (427CT2.1.1): sc-517357

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Datasheets
  • Rab 23 Antibody (427CT2.1.1) is a mouse monoclonal IgG1 Rab 23 antibody provided at 100 µg/ml
  • raised against purified His-tagged Rab 23 protein fragment of human origin
  • recommended for detection of Rab 23 of mouse, rat and human origin by WBIP
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 23 Antibody (427CT2.1.1). This work is in progress.

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    Rab 23 Antibody (427CT2.1.1) is a mouse monoclonal IgG1 antibody that detects Rab 23 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Rab 23 antibody (427CT2.1.1) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins, which are crucial for intracellular transport and signal transduction mediated by small GTPases. Rab 23 is primarily located on the cytoplasmic side of the cell membrane, where Rab 23 plays a vital role in the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi complex and secretory vesicles. Proper functioning of Rab 23 is essential for maintaining cellular homeostasis, as Rab 23 facilitates the movement of carrier vesicles and is integral to endocytic pathways. Disruptions in Rab 23 function due to mutations in its encoding gene can lead to severe developmental disorders, such as Carpenter syndrome, characterized by obesity, cardiac defects, polysyndactyly, and craniosynostosis. By utilizing Rab 23 (427CT2.1.1) antibody, researchers can gain insights into the mechanisms of intracellular transport and the implications of Rab 23 in various diseases, making this tool invaluable in molecular biology research.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Rab 23 Antibody (427CT2.1.1) References:

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.  |  Zhang, QH., et al. 2000. Genome Res. 10: 1546-60. PMID: 11042152
    2. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.  |  Eggenschwiler, JT., et al. 2001. Nature. 412: 194-8. PMID: 11449277
    3. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.  |  Jenkins, D., et al. 2007. Am J Hum Genet. 80: 1162-70. PMID: 17503333
    4. Rab23 GTPase is expressed asymmetrically in Hensen's node and plays a role in the dorsoventral patterning of the chick neural tube.  |  Li, N., et al. 2007. Dev Dyn. 236: 2993-3006. PMID: 17937392
    5. Rab23 regulates differentiation of ATDC5 chondroprogenitor cells.  |  Yang, L., et al. 2008. J Biol Chem. 283: 10649-57. PMID: 18218620
    6. Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.  |  Hou, Q., et al. 2008. Cancer Res. 68: 4623-30. PMID: 18559507
    7. Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord.  |  Günther, T., et al. 1994. Development. 120: 3119-30. PMID: 7720556

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Rab 23 Antibody (427CT2.1.1)

    sc-517357
    100 µg/ml
    $316.00