Rab 22A Antibody (G-7): sc-390726
- Rab 22A Antibody (G-7) is a mouse monoclonal IgG1 κ Rab 22A antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 153-194 mapping at the C-terminus of Rab 22A of human origin
- Rab 22A Antibody (G-7) is recommended for detection of Rab 22A of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Rab 22A Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Rab 22A Antibody (G-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Rab 22A Antibody (G-7) (see ordering information below).
Rab 22A Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Rab 22A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Rab 22A (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Rab 22A protein, also known as MGC16770, is a 194 amino acid protein that plays a crucial role in intracellular trafficking, particularly in the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi apparatus and secretory vesicles. This process is vital for maintaining cellular function and homeostasis, as proteins reach their correct destinations within the cell. Rab 22A acts as a lipid anchor at endosomal and cellular membranes, facilitating the binding of early-endosomal antigen 1 (EEA1) and assisting in the trafficking between endosomes and the Golgi apparatus. The gene encoding Rab 22A is located on human chromosome 20q13.32, and proper function is essential for effective endocytosis and biosynthetic protein transport, highlighting importance in cellular communication and metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rab 22A Antibody (G-7) References:
- The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. | Kauppi, M., et al. 2002. J Cell Sci. 115: 899-911. PMID: 11870209
- Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. | Zhao, H., et al. 2002. Biochem Biophys Res Commun. 293: 1060-5. PMID: 12051767
- Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus. | Mesa, R., et al. 2005. Exp Cell Res. 304: 339-53. PMID: 15748882
- Rab22a regulates the sorting of transferrin to recycling endosomes. | Magadán, JG., et al. 2006. Mol Cell Biol. 26: 2595-614. PMID: 16537905
- Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. | Fukuda, M., et al. 2008. Mol Cell Proteomics. 7: 1031-42. PMID: 18256213
- Membrane traffic and polarization of lipid domains during cytokinesis. | Echard, A. 2008. Biochem Soc Trans. 36: 395-9. PMID: 18481967
- Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. | Olkkonen, VM., et al. 1993. J Cell Sci. 106 (Pt 4): 1249-61. PMID: 8126105
- RAB GTPases expressed in human melanoma cells. | Chen, D., et al. 1997. Biochim Biophys Acta. 1355: 1-6. PMID: 9030196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 22A Antibody (G-7) | sc-390726 | 200 µg/ml | $316.00 | |||
Rab 22A Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-527646 | 200 µg Ab; 10 µg BP | $354.00 | |||
Rab 22A Antibody (G-7): m-IgG1 BP-HRP Bundle | sc-533019 | 200 µg Ab; 20 µg BP | $354.00 | |||
Rab 22A Antibody (G-7) AC | sc-390726 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Rab 22A Antibody (G-7) HRP | sc-390726 HRP | 200 µg/ml | $316.00 | |||
Rab 22A Antibody (G-7) FITC | sc-390726 FITC | 200 µg/ml | $330.00 | |||
Rab 22A Antibody (G-7) PE | sc-390726 PE | 200 µg/ml | $343.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 488 | sc-390726 AF488 | 200 µg/ml | $357.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 546 | sc-390726 AF546 | 200 µg/ml | $357.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 594 | sc-390726 AF594 | 200 µg/ml | $357.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 647 | sc-390726 AF647 | 200 µg/ml | $357.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 680 | sc-390726 AF680 | 200 µg/ml | $357.00 | |||
Rab 22A Antibody (G-7) Alexa Fluor® 790 | sc-390726 AF790 | 200 µg/ml | $357.00 |