Rab 21 Antibody (B16K): sc-81917

Rab 21 Antibody (B16K) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 21 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 21 antibody (B16K) is available as a non-conjugated format. Rab 21 protein plays a crucial role in endosomal trafficking, particularly in integrin transport, which is vital for cell adhesion and motility. Located primarily at the Golgi membrane, Rab 21 (B16K) antibody recognizes proteins involved in carrier vesicle movement, transporting newly synthesized proteins from endoplasmic reticulum to Golgi complex and secretory vesicles. This process maintains cellular functions and facilitates cell-to-cell communication. Rab 21′s interaction with integrin α chain cytoplasmic domains promotes integrin-mediated cell migration and adhesion, critical in various physiological and pathological contexts, including cancer progression. Rab 21 overexpression enhances integrin endosomal trafficking, facilitating increased cell migration and adhesion in cancer cells, making Rab 21 a significant target for cancer biology research and therapeutic interventions.

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Rab 21 Antibody (B16K) References:

1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells.  |  Opdam, FJ., et al. 2000. Eur J Cell Biol. 79: 308-16. PMID: 10887961
2. A role for the small GTPase Rab21 in the early endocytic pathway.  |  Simpson, JC., et al. 2004. J Cell Sci. 117: 6297-311. PMID: 15561770
3. A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms.  |  Khurana, T., et al. 2005. EMBO J. 24: 2254-64. PMID: 15962002
4. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics.  |  Zhang, X., et al. 2006. J Cell Sci. 119: 1053-62. PMID: 16525121
5. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.  |  Pellinen, T., et al. 2006. J Cell Biol. 173: 767-80. PMID: 16754960
6. Structural basis for Rab GTPase activation by VPS9 domain exchange factors.  |  Delprato, A. and Lambright, DG. 2007. Nat Struct Mol Biol. 14: 406-12. PMID: 17450153
7. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5.  |  Zhu, G., et al. 2007. EMBO J. 26: 3484-93. PMID: 17581628
8. Characterization of Rab21-positive tubular endosomes induced by PI3K inhibitors.  |  Egami, Y. and Araki, N. 2008. Exp Cell Res. 314: 729-37. PMID: 18162182
9. [Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor].  |  Pal'gova, IV., et al. 2007. Mol Biol (Mosk). 41: 1009-13. PMID: 18318119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 21 Antibody (B16K) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 21 Antibody (B16K) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 21 Antibody (B16K) Specifications

Alternate Product Name: Rab 21

Product Clone Name: B16K

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 116-226

Epitope Target: Rab 21

Epitope Species: human

Product Reactivity/Detection: Rab 21

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Rab 21 Antibody (B16K): N/A