Rab 21 Antibody (170B2Q): sc-517620
- Rab 21 Antibody (170B2Q) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-225 representing full length Rab 21 of human origin
- recommended for detection of Rab 21 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Rab 21 Antibody (170B2Q). This work is in progress.
Rab 21 Antibody (170B2Q) is a mouse monoclonal IgG2b antibody that detects Rab 21 in human samples through western blotting (WB). Rab 21 is a crucial member of the Rab family of proteins, which are integral to the processes of endocytosis and biosynthetic protein transport. Rab 21 (170B2Q) antibody targets a protein predominantly localized to the Golgi membrane, where Rab 21 plays a vital role in the endosomal trafficking of integrins, which are essential for cell motility and adhesion. By associating with the cytoplasmic domains of integrin α chains, Rab 21 facilitates the movement of these integrins, thereby influencing cellular behaviors such as migration and adhesion, particularly in cancer cells. The overexpression of Rab 21 has been shown to enhance the endosomal trafficking of integrins, promoting increased cell migration and adhesion, which underscores its importance in both normal physiological processes and pathological conditions like cancer. Rab 21 (170B2Q) monoclonal antibody serves as an invaluable tool for researchers studying these critical cellular mechanisms and their implications in disease.
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Rab 21 Antibody (170B2Q) References:
- Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. | Opdam, FJ., et al. 2000. Eur J Cell Biol. 79: 308-16. PMID: 10887961
- A role for the small GTPase Rab21 in the early endocytic pathway. | Simpson, JC., et al. 2004. J Cell Sci. 117: 6297-311. PMID: 15561770
- A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. | Khurana, T., et al. 2005. EMBO J. 24: 2254-64. PMID: 15962002
- Structural basis for Rab GTPase activation by VPS9 domain exchange factors. | Delprato, A. and Lambright, DG. 2007. Nat Struct Mol Biol. 14: 406-12. PMID: 17450153
- Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. | Zhu, G., et al. 2007. EMBO J. 26: 3484-93. PMID: 17581628
- Characterization of Rab21-positive tubular endosomes induced by PI3K inhibitors. | Egami, Y. and Araki, N. 2008. Exp Cell Res. 314: 729-37. PMID: 18162182
- [Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor]. | Pal'gova, IV., et al. 2007. Mol Biol (Mosk). 41: 1009-13. PMID: 18318119
- Gene sequence, developmental expression, and protein phosphorylation of RAB-17 in maize. | Vilardell, J., et al. 1990. Plant Mol Biol. 14: 423-32. PMID: 2151715
- Abscisic acid and water-stress induce the expression of a novel rice gene. | Mundy, J. and Chua, NH. 1988. EMBO J. 7: 2279-86. PMID: 2973410
- The new landscape of differentially expression proteins in placenta tissues of gestational diabetes based on iTRAQ proteomics. | Ge, L., et al. 2023. Placenta. 131: 36-48. PMID: 36473392
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 21 Antibody (170B2Q) | sc-517620 | 100 µg/ml | $316.00 |