Rab 2 Antibody (G-9): sc-133059
- Rab 2 Antibody (G-9) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-212 representing full length Rab 2AA of human origin
- recommended for detection of Rab 2A and Rab 2B of mouse, rat and human origin by WB, IP, IF and ELISA; may cross-react with other Rab family members
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Rab 2 Antibody (G-9) for WB applications. This reagent is now offered in a bundle with Rab 2 Antibody (G-9) (see ordering information below).
Rab 2 Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects Rab 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Rab 2, also known as Ras-related protein Rab-2A or RAB2A, is a crucial member of the small Rab family and the GTPase superfamily, playing a vital role in the transport of proteins from the endoplasmic reticulum to the Golgi complex. This transport process ensures newly synthesized proteins are correctly processed and delivered to their destinations, which is critical for maintaining cellular homeostasis and facilitating communication between organelles. The proper localization and function of Rab 2 are particularly important in secretory pathways and endocytosis, where disruptions can lead to various diseases, including neurodegenerative disorders and cancer. Anti-Rab 2 antibody (G-9) provides a reliable tool for researchers studying these pathways and the implications of Rab protein function in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rab 2 Antibody (G-9) References:
- Rab2 requires PKC iota/lambda to recruit beta-COP for vesicle formation. | Tisdale, EJ. 2000. Traffic. 1: 702-12. PMID: 11208158
- Rab2 purification and interaction with protein kinase C iota/lambda and glyceraldehyde-3-phosphate dehydrogenase. | Tisdale, EJ. 2005. Methods Enzymol. 403: 381-91. PMID: 16473604
- Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase C{iota} to associate with microtubules and to recruit dynein. | Tisdale, EJ., et al. 2009. J Biol Chem. 284: 5876-84. PMID: 19106097
- Rab2 promotes autophagic and endocytic lysosomal degradation. | Lőrincz, P., et al. 2017. J Cell Biol. 216: 1937-1947. PMID: 28483915
- RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. | Ding, X., et al. 2019. Autophagy. 15: 1774-1786. PMID: 30957628
- Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi. | Götz, TWB., et al. 2021. J Cell Biol. 220: PMID: 33822845
- Rab2 drives axonal transport of dense core vesicles and lysosomal organelles. | Lund, VK., et al. 2021. Cell Rep. 35: 108973. PMID: 33852866
- Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. | Zhao, X., et al. 2021. J Mol Med (Berl). 99: 1639-1654. PMID: 34453183
- Rab2 stimulates LC3 lipidation on secretory membranes by noncanonical autophagy. | J Tisdale, E. and R Artalejo, C. 2023. Exp Cell Res. 429: 113635. PMID: 37201743
- Comprehensive knockout analysis of the RAB family small GTPases reveals an overlapping role of RAB2 and RAB14 in autophagosome maturation. | Haga, K. and Fukuda, M. 2025. Autophagy. 21: 21-36. PMID: 38953305
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rab 2 Antibody (G-9) | sc-133059 | 200 µg/ml | $316.00 | |||
Rab 2 Antibody (G-9): m-IgG2b BP-HRP Bundle | sc-548483 | 200 µg Ab; 10 µg BP | $354.00 |