Molecular structure of (R)-(+)-Warfarin, CAS Number: 5543-58-8
(R)-(+)-Warfarin (CAS 5543-58-8)
Alternate Names:
R-(+)-3-Acetonybenzyl)-4-hydroxycoumarin
Application:
(R)-(+)-Warfarin is a CYP1A2/3A4 substrate
CAS Number:
5543-58-8
Molecular Weight:
308.33
Molecular Formula:
C19H16O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-(+)-Warfarin is a stereoisomer of the compound warfarin, investigated in the field of stereochemistry and its influence on biological activity. Research often focuses on its interaction with the vitamin K epoxide reductase (VKOR) enzyme, as this relationship is central to understanding the stereoselective aspects of warfarin′s anticoagulant function. Additionally, studies on (R)-(+)-Warfarin delve into its binding affinity with plasma proteins, which is integral for determining its distribution and elimination kinetics. Moreover, the compound′s role in the study of rodent physiology and behavior is of interest due to its original use as a rodenticide, providing insights into the management of pest populations through anticoagulant means.
(R)-(+)-Warfarin (CAS 5543-58-8) References
- Effect of ubidecarenone on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. | Zhou, S. and Chan, E. 2001. Drug Metabol Drug Interact. 18: 99-122. PMID: 11460879
- In vivo effect of 5- and 8-methoxypsoralens and cimetidine on R,S-warfarin metabolism in rat. | Szutowski, MM., et al. 2002. J Appl Toxicol. 22: 327-32. PMID: 12355562
- Gender differences in pharmacokinetics of oral warfarin in rats. | Zhu, X. and Shin, WG. 2005. Biopharm Drug Dispos. 26: 147-50. PMID: 15776499
- Phase II metabolism of warfarin in primary culture of adult rat hepatocytes. | Jansing, RL., et al. 1992. Mol Pharmacol. 41: 209-15. PMID: 1732719
- Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes. | Baker, MT., et al. 1991. Biochem Pharmacol. 41: 1691-9. PMID: 2043158
- Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice. | Taki, Y., et al. 2012. Phytomedicine. 19: 177-82. PMID: 21802929
- Metabolic profiling of HepG2 cells incubated with S(-) and R(+) enantiomers of anti-coagulating drug warfarin. | Bai, J., et al. 2011. Metabolomics. 7: 353-362. PMID: 21949493
- Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation. | Hosoi, Y., et al. 2012. Biochem Pharmacol. 84: 1691-5. PMID: 23041648
- Effects of etravirine on the pharmacokinetics and pharmacodynamics of warfarin in rats. | John, J., et al. 2013. Br J Pharmacol. 168: 1851-8. PMID: 23215758
- [Effect of Shuxuetong injection on anticoagulant effect of warfarin in rats]. | Zhao, HF., et al. 2017. Zhongguo Zhong Yao Za Zhi. 42: 982-988. PMID: 28994544
- Resveratrol stereoselectively affected (±)warfarin pharmacokinetics and enhanced the anticoagulation effect. | Huang, TY., et al. 2020. Sci Rep. 10: 15910. PMID: 32985569
- Bidirectional Influences of Cranberry on the Pharmacokinetics and Pharmacodynamics of Warfarin with Mechanism Elucidation. | Yu, CP., et al. 2021. Nutrients. 13: PMID: 34579096
- Effects of induction on R- and S-warfarin and metabolite concentrations in rat plasma. | Fasco, MJ. and Cashin, MJ. 1980. Toxicol Appl Pharmacol. 56: 101-9. PMID: 7444959
Substrate of:
CYP1A2, and CYP3A4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(+)-Warfarin, 5 mg | sc-255498 | 5 mg | $615.00 |