R-cadherin Antibody (48): sc-136048
- R-cadherin Antibody (48) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 22-201 of R-cadherin of mouse origin
- recommended for detection of R-cadherin of mouse and rat origin by WB and IP
- See N/R-cadherin (H-4): sc-271386 for R-cadherin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for R-cadherin Antibody (48). This work is in progress.
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R-cadherin Antibody (48) is a mouse monoclonal IgG1 antibody that recognizes R-cadherin in mouse and rat samples through western blotting (WB) and immunoprecipitation (IP). R-cadherin, also known as cadherin-4, belongs to the cadherin family of calcium-dependent adhesion molecules essential for maintaining tissue integrity and facilitating morphogenetic processes. Anti-R-cadherin antibody (48) targets a protein primarily located in the cell membrane, where R-cadherin mediates cell-cell adhesion, influencing cellular organization and communication. R-cadherin expression in the retina and involvement in striated muscle and epithelial tissue development highlights R-cadherin′s significance in developmental biology and tissue homeostasis. R-cadherin′s extracellular domain, featuring five homologous repeats, enables binding specificity, while R-cadherin′s intracellular domain interacts with cytoplasmic proteins like catenin β to regulate function and stability. R-cadherin monoclonal antibody (48) serves as a valuable tool for studying cell adhesion dynamics and molecular mechanisms in tissue development and maintenance.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
R-cadherin Antibody (48) References:
- Expression of R-cadherin and N-cadherin by cell groups and fiber tracts in the developing mouse forebrain: relation to the formation of functional circuits. | Obst-Pernberg, K., et al. 2001. Neuroscience. 106: 505-33. PMID: 11591453
- R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. | Andrews, GL. and Mastick, GS. 2003. J Neurosci. 23: 9873-80. PMID: 14586016
- R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation. | Slater, SC., et al. 2004. Arterioscler Thromb Vasc Biol. 24: 1204-10. PMID: 15117735
- R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina. | Inuzuka, H., et al. 1991. Neuron. 7: 69-79. PMID: 1712604
- R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase. | Kucharczak, J., et al. 2008. Cancer Res. 68: 6559-68. PMID: 18701479
- Small GTPase Rho regulates R-cadherin through Dia1/profilin-1. | Bonacci, TM., et al. 2012. Cell Signal. 24: 2102-10. PMID: 22820501
- Efficient isolation and proteomic analysis of cell plasma membrane proteins in gastric cancer reveal a novel differentiation and progression related cell surface marker, R-cadherin. | Chen, B., et al. 2016. Tumour Biol. 37: 11775-11787. PMID: 27029387
- Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. | Matsunami, H., et al. 1993. J Cell Sci. 106 (Pt 1): 401-9. PMID: 8270638
- A potential role of R-cadherin in striated muscle formation. | Rosenberg, P., et al. 1997. Dev Biol. 187: 55-70. PMID: 9224674
- Involvement of R-cadherin in the early stage of glomerulogenesis. | Goto, S., et al. 1998. J Am Soc Nephrol. 9: 1234-41. PMID: 9644633
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R-cadherin Antibody (48) | sc-136048 | 50 µg/0.5 ml | $322.00 |