Molecular structure of R(−)-α-Methylhistamine Dihydrochloride, CAS Number: 75614-89-0
R(−)-α-Methylhistamine Dihydrochloride (CAS 75614-89-0)
Application:
R(−)-α-Methylhistamine Dihydrochloride is a selective H3 histamine receptor agonist
CAS Number:
75614-89-0
Molecular Weight:
198.09
Molecular Formula:
C6H13Cl2N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent and selective H3 histamine receptor agonist which crosses the blood-brain barrier. It inhibits histamine synthesis and release.
R(−)-α-Methylhistamine Dihydrochloride (CAS 75614-89-0) References
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- Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. | Yu, Y., et al. 2001. Eur J Pharmacol. 419: 55-9. PMID: 11348630
- Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum. | De Man, JG., et al. 2001. Br J Pharmacol. 133: 695-707. PMID: 11429394
- Effects of histamine precursor and (R)-alpha-methylhistamine on the avoidance response in rats. | Rubio, S., et al. 2001. Behav Brain Res. 124: 177-81. PMID: 11640971
- Improvement of spatial memory by (R)-alpha-methylhistamine, a histamine H(3)-receptor agonist, on the Morris water-maze in rat. | Rubio, S., et al. 2002. Behav Brain Res. 129: 77-82. PMID: 11809497
- Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. | Xu, C., et al. 2004. J Physiol. 561: 657-70. PMID: 15486020
- Role of the histamine system in nefopam-induced antinociception in mice. | Girard, P., et al. 2004. Eur J Pharmacol. 503: 63-9. PMID: 15496297
- Synergistic interaction between fentanyl and the histamine H3 receptor agonist R-(alpha)-methylhistamine, on the inhibition of nociception and plasma extravasation in mice. | Poveda, R., et al. 2006. Eur J Pharmacol. 541: 53-6. PMID: 16762339
- Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine. | Kitanaka, J., et al. 2011. Neurochem Res. 36: 1824-33. PMID: 21573995
- Differential expression and signaling of the human histamine H3 receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells. | Nieto-Alamilla, G., et al. 2018. J Recept Signal Transduct Res. 38: 141-150. PMID: 29557708
- Compound 48/80 reduces the crop-emptying rate, likely through a histamine-associated pathway in chicks. | Tachibana, T., et al. 2019. Domest Anim Endocrinol. 66: 57-63. PMID: 30472035
- The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats. | Alachkar, A., et al. 2019. Molecules. 24: PMID: 31739417
Activator of:
Histamine H3 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
R(−)-α-Methylhistamine Dihydrochloride, 100 mg | sc-208217 | 100 mg | $460.00 |